Variation of 24-hour intraocular pressure in healthy individuals - Right eye versus left eye
Variation of 24-hour intraocular pressure in healthy individuals - Right eye versus left eye
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DOI：
10.1016/j.ophtha.2005.05.007
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发表时间：
2005-10-01
期刊：
影响因子：
13.7
通讯作者：
Weinreb, RN
中科院分区：
文献类型：
--
作者：
Liu, JHK;Sit, AJ;Weinreb, RN
目的：降眼压药物单眼治疗试验的一个假设是双眼眼压的对称性变化。我们评估健康个体双眼24小时眼压变化是否相似。设计：受试者为实验对象。参与者：91名健康个体。方法：我们回顾了38名年轻(18-25岁)和53名老年(40-74岁)实验者在睡眠实验室中24小时的双眼眼压数据。在16小时的昼夜/清醒期间和8小时的夜间/睡眠期间，用气压计每隔2小时测量一次坐位和仰卧位的眼压。测量总是先在右眼进行。比较不同年龄组双眼在办公时间、昼夜时段、夜间时段和24小时时段的平均眼压、眼压峰值、眼低谷和眼压极差。主要观察指标：双眼眼压。结果：各年龄组习惯性体位(日间坐位和夜间仰卧)和24小时仰卧位的双眼眼压变化规律相似。在所定义的时间段内，右眼的平均眼压、峰值眼压和低谷眼压均略高于左眼。除青年组白天仰卧位眼压不同外，其余眼压变化范围均无差异。24小时仰卧位眼压的余弦拟合表明，估计的相位计时或两眼之间的24小时变化没有差异。单对左右眼眼压的决定系数在0.311~0.741之间。结论：左右眼24小时眼压变化相似。然而，由于双眼之间的关联强度仅为中等，使用单对右眼和左眼眼压测量进行单眼治疗试验可能很困难。
Purpose: An assumption for the one-eye therapeutic trial of ocular hypotensive drugs is the symmetrical variation of intraocular pressure (IOP) between the two eyes. We evaluated whether or not 24-hour variations of IOP in the two eyes are similar in healthy individuals.Design: Experimental study with human subjects.Participants: Ninety-one healthy individuals.Methods: We reviewed bilateral IOP data collected from 38 younger (18-25 years) and 53 older (40-74 years) experimental subjects housed for 24 hours in a sleep laboratory. Intraocular pressure was measured every 2 hours using a pneumatonometer in the sitting and supine positions during the 16-hour diurnal/wake period and in the supine position during the 8-hour nocturnal/sleep period. Measurements were always taken first in the right eye. For each age group, the two eyes' means, peaks, troughs, and ranges of IOP during office hours, the diurnal period, the nocturnal period, and the 24-hour period were compared. The coefficient of determination was used to examine the strength of association between the right and left IOPs.Main Outcome Measures: Bilateral IOP.Results: For each age group, the profiles of IOP variations were similar in the two eyes with either the habitual body positions (diurnal sitting and nocturnal supine) or the 24-hour supine position. Mean, peak, and trough IOPs in the right eye were slightly higher than those in the left eye during the defined periods. There was no difference in the IOP range, except for the supine IOP in the younger group during the diurnal period. Cosine fits of the 24-hour supine IOP indicate no difference in the estimated phase timing or the 24-hour variation between the two eyes. Coefficients of determination for single pairs of right and left IOPs were in the range of 0.311 to 0.741.Conclusion: Variations of 24-hour IOP in the right and left eyes are similar. However, because the strength of association between the two eyes is only moderate, it may be difficult to perform a one-eye therapeutic trial using single pairs of right and left eye IOP measurements.