Isoforms of acetyl-CoA carboxylase: structures, regulatory properties and metabolic functions
Isoforms of acetyl-CoA carboxylase: structures, regulatory properties and metabolic functions
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DOI：
10.1042/bst0251232
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发表时间：
1997-11-01
影响因子：
3.9
通讯作者：
Boone, AN
中科院分区：
文献类型：
--
作者：
Brownsey, RW;Zhande, R;Boone, AN
乙酰辅酶A羧化酶（ACC; EC 6.4. 1.2)催化丙二酰辅酶A的形成，丙二酰辅酶A作为代谢底物和特定蛋白质活性的调节剂是必需的。丙二酰辅酶A是脂肪酸合酶（FAS）、聚酮化合物脱氢酶（在植物、真菌和细菌中）和脂肪酰基链延长系统的底物。作为一种变构调节剂，丙二酰辅酶A有效地抑制肉毒碱棕榈酰转移酶-I（CPT-I），对中间代谢和细胞分泌功能具有深远的影响。ACC对脂肪酸生物合成和β-氧化的通量控制有重要贡献，并且受到一系列相互作用机制的影响，这些机制决定了组织特异性表达和特异性酶活性。ACC酶学的详细综述出现在20世纪80年代后期[1 -31]，因此我们专注于自1990年以来的选定发展，其中最强调哺乳动物多功能ACC多肽的性质。我们只简要讨论ACC基因的结构和调控，因为这些方面在其他地方讨论过[4]。
Acetyl-CoA carboxylase (ACC; EC 6.4. 1.2) catalyses the formation of malonyl-CoA, which is essential as a metabolic substrate and as a modulator of specific protein activity. Malonyl-CoA is a substrate for fatty acid synthase (FAS), for polyketide synthases (in plants, fungi and bacteria) and for fatty acyl chain-elongation systems. As an allosteric modulator, malonyl-CoA potently inhibits carnitine palmitoyltransferase-I (CPT-I), with far-reaching effects on intermediary metabolism and cell secretory functions. ACC contributes importantly to flux control in fatty acid biosynthesis and b-oxidation and is subject to a range of interacting mechanisms that dictate tissue-specific expression and specific enzyme activity. Detailed reviews of ACC enzymology appeared in the late 1980s [l-31, so we focus on selected developments since 1990, with most emphasis on the properties of the mammalian multifunctional ACC polypeptides. We discuss the structure and regulation of the ACC genes only briefly, since these aspects are dealt with elsewhere [4].