Self-assembled cationic peptide nanoparticles as an efficient antimicrobial agent
Self-assembled cationic peptide nanoparticles as an efficient antimicrobial agent
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DOI：
10.1038/nnano.2009.153
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发表时间：
2009-07-01
影响因子：
38.3
通讯作者：
Yang, Yi-Yan
中科院分区：
文献类型：
--
作者：
Liu, Lihong;Xu, Kaijin;Yang, Yi-Yan
抗菌阳离子肽之所以引起人们的兴趣，是因为它们可以对抗多重耐药微生物。大多数肽形成a-螺旋或p -片状结构，可以插入并随后分解带负电荷的细菌细胞表面。在这里，我们展示了一类由两亲肽自组装形成的新型核壳纳米颗粒对一系列细菌，酵母和真菌具有很强的抗菌性能。纳米颗粒对小鼠金黄色葡萄球菌感染显示出很高的治疗指数，并且比未组装的肽更有效。利用金黄色葡萄球菌感染的脑膜炎兔子，我们发现纳米颗粒可以穿过血脑屏障，抑制感染大脑中的细菌生长。总的来说，这些纳米颗粒是很有前途的抗菌剂，可用于治疗脑感染和其他传染病。
Antimicrobial cationic peptides are of interest because they can combat multi-drug-resistant microbes. Most peptides form a-helices or P-sheet-like structures that can insert into and subsequently disintegrate negatively charged bacterial cell surfaces. Here, we show that a novel class of core-shell nanoparticles formed by self-assembly of an amphiphilic peptide have strong antimicrobial properties against a range of bacteria, yeasts and fungi. The nanoparticles show a high therapeutic index against Staphylococcus aureus infection in mice and are more potent than their unassembled peptide counterparts. Using Staphylococcus aureus-infected meningitis rabbits, we show that the nanoparticles can cross the blood-brain barrier and suppress bacterial growth in infected brains. Taken together, these nanoparticles are promising antimicrobial agents that can be used to treat brain infections and other infectious diseases.