Gender differences in human cortical synaptic density
Gender differences in human cortical synaptic density
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DOI：
10.1073/pnas.0803652105
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发表时间：
2008-09-23
影响因子：
11.1
通讯作者：
DeFelipe, J.
中科院分区：
文献类型：
--
作者：
Alonso-Nanclares, L.;Gonzalez-Soriano, J.;DeFelipe, J.
男性和女性的某些认知功能不同，尽管这些差异背后的解剖学和功能基础尚不清楚。由于大脑皮层活动与大脑高级功能直接相关，因此在寻找认知性别差异可能的结构相关性时，许多研究都集中在大脑皮层上。然而，在突触水平上可能存在的性别差异尚无研究。在目前的工作中，我们使用了立体学和相关的光学和电子显微镜来显示男性在颞叶新皮层的所有皮层层的突触密度明显高于女性。这些差异可能代表了一种微观解剖学基础，有助于大脑活动的功能性性别差异。
Certain cognitive functions differ in men and women, although the anatomical and functional substrates underlying these differences remain unknown. Because neocortical activity is directly related with higher brain function, numerous studies have focused on the cerebral cortex when searching for possible structural correlates of cognitive gender differences. However, there are no studies on possible gender differences at the synaptic level. In the present work we have used stereological and correlative light and electron microscopy to show that men have a significantly higher synaptic density than women in all cortical layers of the temporal neocortex. These differences may represent a microanatomical substrate contributing to the functional gender differences in brain activity.