Multi-laboratory performance assessment of diffuse optics instruments: the BitMap exercise.
Multi-laboratory performance assessment of diffuse optics instruments: the BitMap exercise.
复制标题
DOI：
10.1117/1.jbo.27.7.074716
复制
发表时间：
2022-06
影响因子：
3.5
通讯作者：
Pifferi A
中科院分区：
文献类型：
--
作者：
Lanka P;Yang L;Orive-Miguel D;Veesa JD;Tagliabue S;Sudakou A;Samaei S;Forcione M;Kovacsova Z;Behera A;Gladytz T;Grosenick D;Hervé L;Durduran T;Bejm K;Morawiec M;Kacprzak M;Sawosz P;Gerega A;Liebert A;Belli A;Tachtsidis I;Lange F;Bale G;Baratelli L;Gioux S;Alexander K;Wolf M;Sekar SKV;Zanoletti M;Pirovano I;Lacerenza M;Qiu L;Ferocino E;Maffeis G;Amendola C;Colombo L;Frabasile L;Levoni P;Buttafava M;Renna M;Di Sieno L;Re R;Farina A;Spinelli L;Dalla Mora A;Contini D;Taroni P;Tosi A;Torricelli A;Dehghani H;Wabnitz H;Pifferi A
多实验室倡议在性能评估和标准化中是必不可少的——这对于将生物光子学引入成熟的临床应用至关重要——建立协议和开发参考组织模型，所有这些都将允许通用仪器进行比较。本文提出了最大的近红外漫射光学性能评估的多实验室比较，涉及28个仪器和12个机构，基于三个综合协议（BIP， MEDPHOT和NEUROPT）在三个组织模型套件上实施的总共8个实验。从数据集中提取了20个综合指标，其中一些指标在这里重新定义。该演习源于由欧洲委员会资助的创新培训网络位图，并扩大到包括其他欧洲实验室。基于不同的方法（时域/频域/连续波），考虑了各种各样的漫射光学仪器，这些仪器处于不同的成熟阶段，并为不同的应用（例如，血氧测定、光谱和成像）而设计。这项研究强调了硬件性能的实质性差异（例如，响应率90年，暗计数率40年，时间分辨率10年）。在均匀光学性质的估计中，有一半的系统的一致性在中位数的12%以内，时间稳定性超过1小时，每天的可重复性为。其他测试包括线性、串扰、不确定度和光学不均匀性检测。这个广泛的多实验室练习提供了近红外漫射光学仪器的详细评估，并可用于参考分级。数据集很快就会出现在开放的数据存储库中，可以通过多种方式进行评估，例如，比较不同的分析工具或研究硬件实现的影响。
Multi-laboratory initiatives are essential in performance assessment and standardization—crucial for bringing biophotonics to mature clinical use—to establish protocols and develop reference tissue phantoms that all will allow universal instrument comparison. The largest multi-laboratory comparison of performance assessment in near-infrared diffuse optics is presented, involving 28 instruments and 12 institutions on a total of eight experiments based on three consolidated protocols (BIP, MEDPHOT, and NEUROPT) as implemented on three kits of tissue phantoms. A total of 20 synthetic indicators were extracted from the dataset, some of them defined here anew. The exercise stems from the Innovative Training Network BitMap funded by the European Commission and expanded to include other European laboratories. A large variety of diffuse optics instruments were considered, based on different approaches (time domain/frequency domain/continuous wave), at various stages of maturity and designed for different applications (e.g., oximetry, spectroscopy, and imaging). This study highlights a substantial difference in hardware performances (e.g., nine decades in responsivity, four decades in dark count rate, and one decade in temporal resolution). Agreement in the estimates of homogeneous optical properties was within 12% of the median value for half of the systems, with a temporal stability of over 1 h, and day-to-day reproducibility of . Other tests encompassed linearity, crosstalk, uncertainty, and detection of optical inhomogeneities. This extensive multi-laboratory exercise provides a detailed assessment of near-infrared Diffuse optical instruments and can be used for reference grading. The dataset—available soon in an open data repository—can be evaluated in multiple ways, for instance, to compare different analysis tools or study the impact of hardware implementations.
影响因子：
4.6
作者：
Weigl W;Milej D;Gerega A;Toczyłowska B;Sawosz P;Kacprzak M;Janusek D;Wojtkiewicz S;Maniewski R;Liebert A
通讯作者：
Liebert A