Spongy matrix of hyaluronic acid and collagen as a cultured dermal substitute: evaluation in an animal test.
Spongy matrix of hyaluronic acid and collagen as a cultured dermal substitute: evaluation in an animal test.
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DOI：
10.1007/s100470300010
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发表时间：
2003-01-01
期刊：
影响因子：
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通讯作者：
Kuroyanagi, Yoshimitsu
中科院分区：
文献类型：
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作者：
Kubo, Kentaro;Kuroyanagi, Yoshimitsu
作者开发了一种由透明质酸 (HA) 和去端肽胶原 (Col) 组成的两层海绵状基质，作为培养真皮替代品 (CDS)。将这种海绵状基质应用于Sprague-Dawley大鼠背部的全层皮肤缺损处，并观察2周的伤口情况。将一块两层海绵状基质敷在伤口上，在其上敷上市售的聚氨酯薄膜敷料。宏观和组织学评估均表明双层海绵基质能够在早期制备高度血管化的肉芽组织。这些发现表明这种类型的海绵基质可用作 CDS。
The authors have developed a two-layered spongy matrix composed of hyaluronic acid (HA) and atelo-collagen (Col) as a cultured dermal substitute (CDS). This spongy matrix was applied to a full-thickness skin defect on the dorsum of Sprague-Dawley rats, and the wound conditions were observed over a period of 2 weeks. A piece of two-layered spongy matrix was applied to the wound, over which a commercially available polyurethane film dressing was applied. Both the macroscopic and the histological evaluations indicate that the two-layered spongy matrix is able to prepare a highly vascularized granulation tissue at an early stage. These findings suggest that this type of spongy matrix would be useful as a CDS.