Therapeutic Nanosystem Consisting of Singlet-Oxygen-Responsive Prodrug and Photosensitizer Excited by Two-Photon Light.
Therapeutic Nanosystem Consisting of Singlet-Oxygen-Responsive Prodrug and Photosensitizer Excited by Two-Photon Light.
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DOI：
10.1021/acsmedchemlett.7b00394
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发表时间：
2018-01
影响因子：
4.2
通讯作者：
Yi Lin;Xiao-Fang Jiang;Xiangyan Duan;Fang Zeng;Bo Wu;Shuizhu Wu
中科院分区：
文献类型：
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作者：
Yi Lin;Xiao-Fang Jiang;Xiangyan Duan;Fang Zeng;Bo Wu;Shuizhu Wu
利用光作为唯一的刺激，利用产生的单线态氧作为治疗剂和触发器来激活化学药物释放，可以充分发挥光的优势，通过化疗和光动力治疗相结合来提高治疗效果。本文通过在磷脂囊泡中嵌入荧光光敏剂和前药，开发了一种脂质体药物系统。在单光子或双光子光照射下，光敏剂产生单线态氧，从而去除前药的保护基团，随后导致活性药物氯苯的释放。通过O21和氯霉素的联合作用，实现了对癌细胞高度可控的细胞毒性作用。此外，荧光光敏剂发出荧光信号，作为药物监测剂。该策略可能为癌症治疗提供有效的方法，并为设计光刺激按需治疗系统提供一些有用的见解。
Using light as the sole stimulus and employing the generated singlet oxygen as a therapeutic agent and the trigger to activate chemo-drug release could serve as an elegant way to bring into full play the advantageous features of light and enhance therapeutic efficacy through a combination of chemotherapy and photodynamic therapy. Herein a liposomal drug system has been developed by embedding a fluorescent photosensitizer and a prodrug into phospholipid vesicles. Upon one- or two-photon light irradiation, the photosensitizer generates singlet oxygen, which removes the protecting group of the prodrug and subsequently causes the release of the active drug chlorambucil. With the combined action of O21 and chlorambucil, highly controllable cytotoxicity toward cancer cells was achieved. In addition, the fluorescent photosensitizer gives out fluorescent signal acting as the drug monitoring agent. This strategy may provide an efficient approach for cancer treatment and some useful insights for designing light-stimulated on-demand therapeutic systems.