Secondhand smoke and traffic exhaust confer opposing risks for asthma in normal and overweight children.
Secondhand smoke and traffic exhaust confer opposing risks for asthma in normal and overweight children.
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二手烟和交通尾气给正常儿童和超重儿童带来相反的哮喘风险。
DOI：
10.1002/oby.20941
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Ryan,PatrickH
中科院分区：
文献类型：
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作者：
LeMasters,Grace;Levin,Linda;Bernstein,DavidI;Lockey4th,StephenD;Lockey,JamesE;Burkle,Jeff;KhuranaHershey,GurjitK;Brunst,Kelly;Ryan,PatrickH
目的暴露于二手烟（SHS）和交通相关空气污染（TRAP）中的超细颗粒（UFP）可能引发慢性炎症。据推测，与体重正常的儿童相比，这些暴露之间的关联在超重儿童中会得到加强。方法对 575 名 7 岁儿童的平均终生暴露于 TRAP 和 SHS 以及客观的、医生诊断的哮喘进行了测定。超重的定义是体重指数 (BMI) > 年龄和性别的第 85 个百分位。通过按 BMI 分层的逻辑回归来检查 TRAP 和 SHS 暴露与哮喘之间的关联。结果 共有 131 名儿童超重；超重和正常体重儿童的哮喘患病率分别为 24.4% 和 14.2%。超重儿童接触二手烟与哮喘显着相关（调整比值比 [adjOR] = 3.0；95% 置信区间 [CI] = 1.2, 7.4），但与正常体重儿童无关（adjOR = 1.1；95% CI = 0.4, 2.7）。相比之下，在正常体重儿童中，TRAP 与哮喘显着相关 (adjOR = 1.8; 95% CI = 1.0, 3.4)，但与超重儿童无关 (adjOR = 0.7; 95% CI = 0.4, 2.7)。结论 SHS 和 TRAP 暴露与哮喘之间的关联因儿童体重而改变。儿童的时间活动模式，包括在室内或室外度过的时间，可能会因体重而异，并在这些 UFP 暴露中发挥重要作用。
ObjectiveExposure to ultrafine particles (UFP) in secondhand smoke (SHS) and traffic‐related air pollution (TRAP) may elicit chronic inflammation. It was hypothesized that the association between these exposures would be potentiated in overweight versus normal‐weight children.MethodsAverage lifetime exposure to TRAP and SHS and objective, physician‐diagnosed asthma were determined for 575 children at age 7. Overweight was defined as having a body mass index (BMI)>85th percentile for age and gender. The association between TRAP and SHS exposure and asthma was examined by logistic regression stratified by BMI.ResultsA total of 131 children were overweight; the prevalence of asthma was 24.4% and 14.2% among overweight and normal‐weight children, respectively. Exposure to SHS was significantly associated with asthma among overweight (adjusted odds ratio [adjOR] = 3.0; 95% confidence interval [CI] = 1.2, 7.4) but not normal‐weight children (adjOR = 1.1; 95% CI = 0.4, 2.7). In contrast, TRAP was significantly associated with asthma among normal‐weight (adjOR = 1.8; 95% CI = 1.0, 3.4) but not overweight children (adjOR = 0.7; 95% CI = 0.4, 2.7).ConclusionsThe association between SHS and TRAP exposure and asthma is modified by children's weight. Children's time‐activity patterns, including time spent indoors or outdoors, may vary by weight and play an important role in these UFP exposures.