Prolactin receptors in the brain during pregnancy and lactation: Implications for behavior
Prolactin receptors in the brain during pregnancy and lactation: Implications for behavior
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DOI：
10.1006/hbeh.2001.1698
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发表时间：
2001-09-01
影响因子：
3.5
通讯作者：
Bunn, SJ
中科院分区：
文献类型：
--
作者：
Grattan, DR;Pi, XJ;Bunn, SJ
许多研究已经证明了催乳素对多种脑功能的调节，包括母性行为、催产素神经元的调节、进食和食欲的调节、应激时ACTH分泌的抑制以及生育力的抑制。我们已经观察到显着的变化，催乳素受体的表达在特定的下丘脑核在怀孕和哺乳期。这对催乳素调节的神经元功能具有重要意义。鉴于妊娠和哺乳期间催乳素的高循环水平以及下丘脑中催乳素受体的表达增加，这些功能中的许多功能可能在母体大脑中增强或夸大。母体大脑的适应性使雌性能够表现出适当的行为来喂养和养育她的后代，以适应牛奶生产的营养和代谢需求，并保持适当的激素分泌，以允许牛奶合成，分泌和排出。这篇综述旨在总结催乳素在哺乳期调节下丘脑功能中起关键作用的证据，并讨论催乳素的总体作用是组织和协调妊娠和哺乳期广泛的行为和神经内分泌适应的假设。(C)北京：科学出版社.
Numerous studies have documented prolactin regulation of a variety of brain functions, including maternal behavior, regulation of oxytocin neurons, regulation of feeding and appetite, suppression of ACTH secretion in response to stress, and suppression of fertility. We have observed marked changes in expression of prolactin receptors in specific hypothalamic nuclei during pregnancy and lactation. This has important implications for neuronal functions regulated by prolactin. In light of the high circulating levels of prolactin during pregnancy and lactation and the increased expression of prolactin receptors in the hypothalamus, many of these functions may be enhanced or exaggerated in the maternal brain. The adaptations of the maternal brain allow the female to exhibit the appropriate behavior to feed and nurture her offspring, to adjust to the nutritional and metabolic demands of milk production, and to maintain appropriate hormone secretion to allow milk synthesis, secretion, and ejection. This review aims to summarize the evidence that prolactin plays a key role in regulating hypothalamic function during lactation and to discuss the hypothesis that the overall role of prolactin is to organize and coordinate this wide range of behavioral and neuroendocrine adaptations during pregnancy and lactation. (C) 2001 Academic Press.