Origins of multisynaptic projections from the basal ganglia to rostrocaudally distinct sectors of the dorsal premotor area in macaques
Origins of multisynaptic projections from the basal ganglia to rostrocaudally distinct sectors of the dorsal premotor area in macaques
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DOI：
10.1111/j.1460-9568.2010.07492.x
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发表时间：
2011-01-01
影响因子：
3.4
通讯作者：
Hoshi, Eiji
中科院分区：
文献类型：
--
作者：
Saga, Yosuke;Hirata, Yoshihiro;Hoshi, Eiji
我们研究了猕猴从基底神经节（BG）到背侧运动前区的多突触投射的组织。将狂犬病毒注入背侧运动前区尾侧的吻侧区（F2r）和背侧运动前区尾侧的尾侧区（F2c）后，在苍白球内段（GPi）和黑质网状部（SNr）出现二级神经元标记。注射F2c后，在尾腹侧部分发现标记的GPi神经元，注射F2r后，在吻尾侧中间水平的背侧部分发现标记的GPi神经元。在SNr中，F2c和F2r注射分别导致尾侧或喙侧部分的标记。随后，在苍白球（GPe）的外部段，丘脑底核（ESTA）和纹状体中观察到三级神经元标记。F2c注射后，标记的神经元在GPe的广泛的领土，而F2r注射后，标记的神经元往往被限制在吻侧和背侧部分。在海马，F2c注射导致广泛的标记在核，而F2r注射导致标记在腹侧部分。注射F2r和F2c后，在纹状体细胞桥区域和邻近区域以及腹侧纹状体中广泛观察到标记神经元。目前的结果表明，起源的多突触预测F2C和F2R在BG分离的输出站的BG，而混合，而不是隔离是显而易见的，相对于他们的输入站。
We examined the organization of multisynaptic projections from the basal ganglia (BG) to the dorsal premotor area in macaques. After injection of the rabies virus into the rostral sector of the caudal aspect of the dorsal premotor area (F2r) and the caudal sector of the caudal aspect of the dorsal premotor area (F2c), second-order neuron labeling occurred in the internal segment of the globus pallidus (GPi) and the substantia nigra pars reticulata (SNr). Labeled GPi neurons were found in the caudoventral portion after F2c injection, and in the dorsal portion at the rostrocaudal middle level after F2r injection. In the SNr, F2c and F2r injections led to labeling in the caudal or rostral part, respectively. Subsequently, third-order neuron labeling was observed in the external segment of the globus pallidus (GPe), the subthalamic nucleus (STN), and the striatum. After F2c injection, labeled neurons were observed over a broad territory in the GPe, whereas after F2r injection, labeled neurons tended to be restricted to the rostral and dorsal portions. In the STN, F2c injection resulted in extensive labeling over the nucleus, whereas F2r injection resulted in labeling in the ventral portion only. After both F2r and F2c injections, labeled neurons in the striatum were widely observed in the striatal cell bridge region and neighboring areas, as well as in the ventral striatum. The present results revealed that the origins of multisynaptic projections to F2c and F2r in the BG are segregated in the output stations of the BG, whereas intermingling rather than segregation is evident with respect to their input station.