SEROTONIN AND OCTOPAMINE IN THE NEMATODE CAENORHABDITIS-ELEGANS
SEROTONIN AND OCTOPAMINE IN THE NEMATODE CAENORHABDITIS-ELEGANS
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DOI：
10.1126/science.6805073
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
EVANS, PD
中科院分区：
文献类型：
--
作者：
HORVITZ, HR;CHALFIE, M;EVANS, PD
生物胺5-羟色胺和章鱼胺存在于线虫C。优美的5-羟色胺，检测组织化学在整个坐骑，是本地化的2咽神经元，似乎是神经分泌。章鱼胺，确定放射酶的粗提物，可能也是本地化的一些神经元。外源性5-羟色胺和章鱼胺引起C. elegans，这表明这些化合物在生理上起拮抗剂的作用。
The biogenic amines serotonin and octopamine are present in the nematode C. elegans. Serotonin, detected histochemically in whole mounts, is localized in 2 pharyngeal neurons that appear to be neurosecretory. Octopamine, identified radioenzymatically in crude extracts, probably is also localized in a few neurons. Exogenous serotonin and octopamine elicit specific and opposite behavioral responses in C. elegans, suggesting that these compounds function physiologically as antagonists.