Pulmonary Function Tests in Very Low Birth Weight Infants Screened for Pulmonary Hypertension: A Pilot Study.
Pulmonary Function Tests in Very Low Birth Weight Infants Screened for Pulmonary Hypertension: A Pilot Study.
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DOI：
10.1016/j.jpeds.2021.06.046
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
McEvoy CT
中科院分区：
文献类型：
--
作者：
Adair JD;Kelly B;Schilling D;Parkhotyuk K;Gievers L;Kim A;Scottoline B;McEvoy CT
为了比较患有和不患有肺动脉高压的极低出生体重 (VLBW) 婴儿的肺功能测试 (PFT)，特别是呼吸系统阻力 (Rrs) 和顺应性 (Crs)，纳入了在月经后 34 至 38 周 (PMA) 进行 PFT 的婴儿，作为我们针对出生体重 ≤ 1500 克、在 PMA ≥ 34 周需要呼吸支持的婴儿的 PH 筛查指南的一部分。一位儿科心脏病专家审查并估计了右心室或肺动脉压，并将 PH 定义为估计的肺动脉压或右心室压力大于全身压力的一半。根据标准化标准，使用单次呼吸闭塞技术测量 Rrs 和 Crs，并使用氮气冲洗法测量功能残气量。对 12 名患有 PH 的 VLBW 婴儿和 39 名不患有 PH 的 VLBW 婴儿进行了研究。患有PH的人出生体重明显较低，并且胎龄有较低的趋势。各组之间没有其他人口统计学差异。 PH 婴儿的 Rrs 显着增加（119 vs 78 cmH2O/L/sec；调整后的 p 值=0.012），Crs/kg 显着降低（0.71 vs 0.92 mL/cmH2O/kg；P = 0.04）。在这项针对 VLBW 婴儿在 34-38 周 PMA 筛查 PH 的初步研究中，与没有 PH 的婴儿相比，患有 PH 的婴儿的 Rrs 显着升高，Crs 显着降低。需要进行更多研究来进一步对患有 BPD 和 PH 的婴儿进行表型分析。
To compare pulmonary function tests (PFTs), specifically respiratory system resistance (Rrs) and compliance (Crs), in very low birth weight (VLBW) infants with and without pulmonary hypertension Infants were included who had PFTs at 34 to 38 weeks post menstrual age (PMA) as part of our PH screening guidelines for infants born at ≤ 1500 grams requiring respiratory support at ≥34 weeks PMA. One pediatric cardiologist reviewed and estimated right ventricular or pulmonary arterial pressure and defined PH as an estimated pulmonary arterial pressure or right ventricular pressure greater than half systemic pressure. Rrs and Crs were measured with the single breath occlusion technique and functional residual capacity with the nitrogen washout method as per standardized criteria. 12 VLBW infants with and 39 without PH were studied. Those with PH had significantly lower birth weight and a trend toward a lower gestational age. There were no other demographic differences between groups. The infants with PH had significantly increased Rrs (119 versus 78 cmH2O/L/sec; adjusted p value =0.012) and significantly decreased Crs/kg (0.71 vs 0.92 mL/cmH2O/kg; P = .04). In this pilot study of VLBW infants screened for PH at 34-38 weeks PMA, those with PH had significantly increased Rrs and decreased Crs compared with those without PH. Additional studies are needed to further phenotype infants with evolving BPD and PH.
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DOI：
10.1016/j.jpeds.2019.07.074
发表时间：
2020-02
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Lam R;Schilling D;Scottoline B;Platteau A;Niederhausen M;Lund KC;Schelonka RL;MacDonald KD;McEvoy CT
通讯作者：
McEvoy CT
影响因子：
5.1
作者：
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通讯作者：
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影响因子：
5.1
作者：
Krishnan, Usha;Feinstein, Jeffrey A.;Abman, Steven H.
通讯作者：
Abman, Steven H.
DOI：
10.1164/ajrccm.155.1.9001304
发表时间：
1997-01-01
影响因子：
24.7
作者：
Baraldi, E;Filippone, M;Zacchello, F
通讯作者：
Zacchello, F
影响因子：
10
作者：
Doyle, Lex W.;Adams, Anne-Marie;Cheong, Jeanie L.
通讯作者：
Cheong, Jeanie L.