Potential Role for Natural Products in Dental Caries Control.
Potential Role for Natural Products in Dental Caries Control.
复制标题
天然产品在龋齿控制中的潜在作用。
DOI：
--
复制
发表时间：
2019
影响因子：
1.6
通讯作者：
L. Walsh
中科院分区：
文献类型：
--
作者：
Nebu Philip;S. Leishman;L. Walsh
目的
本文讨论了一些最有前景的天然产物的防腐机理，并探讨了将天然产物转化为商业口腔护理产品以控制龋齿的研究方向。
材料和方法
这篇叙述性综述的搜索策略包括进行全面的文献搜索，以获取所有已发表的研究(截至2017年12月)，具体涉及具有防龋作用的天然产品。搜索的数据库是Medline(通过PubMed)、Embase和Web of Science，使用受控词汇和文本单词的组合。所有选定研究的参考文献列表也被手动搜索，以寻找其他相关研究。
结果
近年来，人们对几种天然产品的抗龋性重新产生了兴趣，特别是那些能够在不破坏口腔微生物群的关键健康益处的情况下抑制致龋性或细菌黏附的天然产品。其他为天然产品确定的防龋剂包括可抑制脱矿并增强再矿化从而有益地重新平衡龋齿平衡的植物化学物质，以及可减少含糖食品或饮料造成的产酸挑战的天然不可发酵饮食甜味剂。
结论
天然植物化学物质在预防和控制龋病方面作为抗致龋菌的辅助治疗剂具有巨大的潜力。然而，未来的研究需要针对几个重大挑战，以便将止龋剂天然产品的潜力转化为临床相关的口腔护理产品，用于控制龋齿。
PURPOSE
This paper discusses the cariostatic mechanisms of some of the most promising natural products and explores the research directions that are needed to translate the potential of natural products into commercial oral care products for dental caries control.
MATERIALS AND METHODS
The search strategy for this narrative review involved performing a comprehensive literature search to capture all published studies (up to December 2017) specifically related to natural products with anticaries effects. The databases searched were Medline (via PubMed), Embase and Web of Science, using a combination of controlled vocabulary and text words. The reference list of all selected studies was also manually searched for additional relevant studies.
RESULTS
In recent years there has been renewed interest in the anticariogenic properties of several natural products, especially those that have the ability to inhibit cariogenic virulence properties or bacterial adhesion without disrupting the key health benefits of the resident oral microbiome. Other cariostatic mechanisms identified for natural products include phytochemicals that can inhibit demineralisation and enhance remineralisation thereby beneficially rebalancing the caries equilibrium, and natural non-fermentable dietary sweeteners that can reduce the acidogenic challenge posed by sugar-laden foods or beverages.
CONCLUSION
Natural phytochemicals hold enormous potential as adjunctive therapeutic agents against cariogenic bacteria in the prevention and control of dental caries. However, there are several significant challenges to which future research needs to be directed in order to translate the potential of cariostatic natural products into clinically relevant oral care products for dental caries control.