Theory of frequency response of mechanically driven cardiomyocytes
Theory of frequency response of mechanically driven cardiomyocytes
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DOI：
10.1038/s41598-018-20307-2
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发表时间：
2018-02-02
影响因子：
4.6
通讯作者：
Safran, Samuel A.
中科院分区：
文献类型：
--
作者：
Cohen, Ohad;Safran, Samuel A.
我们从理论上预测并与实验比较，从自发跳动的振荡，外部机械探针诱导的心肌细胞的动态夹带的过渡。与最近的实验结果雅阁，我们预测了作为探针振幅和频率的函数的动力学行为。该理论是基于一个现象学模型的非线性振荡器，由肌动蛋白收缩的动机。通用的行为是独立的详细的，分子的起源的动力学，并与实验一致，我们发现三个制度：自发跳动的自然频率的细胞，夹带跳动的频率的探针，和“爆裂”制度的两个频率交替的时间。我们定量预测的属性的“爆裂”制度作为探头的振幅和频率的函数。此外，我们研究了弱噪声存在下的起搏过程，并解释了这可能与心肌细胞生理学有关。
We theoretically predict and compare with experiments, transitions from spontaneous beating to dynamical entrainment of cardiomyocytes induced by an oscillating, external mechanical probe. In accord with recent experiments, we predict the dynamical behavior as a function of the probe amplitude and frequency. The theory is based on a phenomenological model for a non-linear oscillator, motivated by acto-myosin contractility. The generic behavior is independent of the detailed, molecular origins of the dynamics and, consistent with experiment, we find three regimes: spontaneous beating with the natural frequency of the cell, entrained beating with the frequency of the probe, and a "bursting" regime where the two frequencies alternate in time. We quantitatively predict the properties of the "bursting" regime as a function of the amplitude and frequency of the probe. Furthermore, we examine the pacing process in the presence of weak noise and explain how this might relate to cardiomyocyte physiology.