Ocular sarcoidosis prevalence and clinical features in the Northern Ireland population
Ocular sarcoidosis prevalence and clinical features in the Northern Ireland population
复制标题
北爱尔兰人群眼结节病患病率和临床特征
作者：
Gerard Reid;Michael Williams;M. Compton;G. Silvestri;C. McAvoy
记录北方爱尔兰使用2019年眼结节病国际研讨会（IWOS）分类诊断的眼结节病（OS）病例的患病率。目前没有关于该人群OS的数据。根据IWOS 2019标准确定的OS病例的回顾性病例审查。年中人口估计数用于计算疾病流行率。收集的其他数据包括葡萄膜炎特征、眼部并发症和是否存在仅眼部或多系统疾病。共确定了86例符合OS诊断标准的患者，北方爱尔兰的OS患病率估计为4.5例/100，000。最常见的葡萄膜炎类型为全葡萄膜炎，占36%，最常见的眼部并发症为高眼压，占36%，可检测到的青光眼变化占10%。总的来说，80%的仅表现为眼部结节病的病例随后发生了第二器官受累，发生率为14%/人-年。结节病最常见的眼外部位是肺部。与其他欧洲国家相比，北方爱尔兰人群的OS患病率相对较高。仅表现为眼部受累的OS进展为第二器官受累的患者占80%，发生率为14%/人-年。眼内压升高伴或不伴青光眼损害是常见的发现。如果临床怀疑存在OS，并且淋巴细胞减少症的存在有助于诊断同时使用全身性ACE抑制剂，则应要求进行胸部CT成像。
To record the prevalence of ocular sarcoidosis (OS) cases present in Northern Ireland as diagnosed using the International Workshop on Ocular Sarcoidosis (IWOS) classification, 2019. There are currently no data regarding OS in this population. Retrospective case review of OS cases as identified by IWOS criteria 2019. Mid-year population estimates were used to calculate disease prevalence. Additional data collected included uveitis features, ocular complications and the presence of ocular only or multi-system disease. A total of 86 patients were identified meeting the criteria for a diagnosis of OS, and the prevalence of OS in Northern Ireland was estimated to be 4.5 cases per 100,000. The most common type of uveitis was panuveitis in 36% of cases, and the most common ocular complication was ocular hypertension in 36% of cases and detectable glaucomatous changes in 10%. Overall, 80% of cases presenting with ocular only sarcoidosis subsequently developed second organ involvement at a rate of 14%/person-years. The most common extra-ocular site of sarcoidosis was pulmonary. The Northern Ireland population has a relatively high prevalence of OS compared with other European countries. OS presenting with only ocular involvement progressed to second organ involvement in 80% of patients at a rate of 14%/person-years. Raised intra-ocular pressure with or without glaucomatous damage was a frequent finding. Thoracic CT imaging should be requested if clinical suspicion of OS exists and the presence of lymphopenia has utility in diagnosis with concurrent use of systemic ACE inhibitors.