Effect of particulate matter air pollution on C-reactive protein: a review of epidemiologic studies.
Effect of particulate matter air pollution on C-reactive protein: a review of epidemiologic studies.
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DOI：
10.1515/reveh-2012-0012
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发表时间：
2012
影响因子：
3.9
通讯作者：
Mu L
中科院分区：
文献类型：
--
作者：
Li Y;Rittenhouse-Olson K;Scheider WL;Mu L
炎症反应是一种生物学机制，将颗粒物（PM）空气污染与健康影响联系起来。C-反应蛋白（CRP）是一种重要的急性期反应物，具有显著的促炎特性，在临床上被用作炎症存在和强度的指标。体外和体内动物研究表明，CRP水平增加响应PM暴露，但在流行病学研究中没有一致性。在此，进行了一项系统评价，以检查PM暴露与人类血清CRP水平之间的关联。在儿童中始终发现CRP水平升高，在健康成人中也观察到CRP升高，尽管需要更高的PM暴露峰值水平。PM诱导的CRP反应在慢性炎症性疾病的成年人中并不一致，这可能是因为在这一人群中使用抗炎药物。在8项检查的随机试验中，只有一项干预期较长的试验支持PM暴露对CRP浓度的影响。为了提供确凿的证据，需要进一步的流行病学研究，以更好地量化CRP水平变化的幅度响应PM与明确定义的研究人群和更好地控制各种混杂因素。
Inflammatory response is implicated as a biologic mechanism that links particulate matter (PM) air pollution with health effects. C-reactive protein (CRP), an important acute-phase reactant with profound proinflammatory properties, is used clinically as an indicator of the presence and intensity of inflammation. In vitro and in vivo animal studies suggest that CRP levels increase in response to PM exposure, but there was no consistency in epidemiologic studies. Herein, a systematic review was conducted to examine the association between PM exposure and serum CRP levels in humans. Elevated CRP levels were consistently found among children, and CRP elevations were also observed among healthy adults, albeit requiring higher peak levels of PM exposure. PM-induced CRP responses were not consistently found in adults with chronic inflammatory conditions, perhaps because of the use of anti-inflammatory medications in this population. Of the eight examined randomized trials, only one trial with a longer intervention period supported the effect of PM exposure on CRP concentrations. To provide conclusive evidence, further epidemiologic studies are needed to better quantify the magnitude of CRP level changes in response to PM with well-defined study populations and better control of various confounding factors.