Mucus T helper 2 biomarkers predict chronic rhinosinusitis disease severity and prior surgical intervention.
Mucus T helper 2 biomarkers predict chronic rhinosinusitis disease severity and prior surgical intervention.
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DOI：
10.1002/alr.22160
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发表时间：
2018-10
影响因子：
6.4
通讯作者：
Chandra RK
中科院分区：
文献类型：
--
作者：
Turner JH;Li P;Chandra RK
Chronic rhinosinusitis(CRS) is a diverse clinical syndrome with a heterogeneous pathophysiology. Early attempts to identify CRS endotypes and biomarkers have largely relied on analysis of surgically obtained tissue, thus limiting their practical utility. This study examined the ability of mucus Th2 biomarkers to predict CRS disease severity and clinical characteristics. CRS(n=90) and healthy control subjects(n=17) were prospectively enrolled prior to surgical intervention and mucus levels of IL-4,IL-5,and IL-13 were determined using a multiplex cytometric bead assay. Data for relevant cytokines was then scaled, normalized, and later combined to develop standardized metrics indicative of Th2-associated inflammation. Th2-high and Th2-low subgroups were consequently identified and validated against factors associated with disease severity and clinical outcomes. Mucus levels of IL-5, and IL-13 were elevated in CRS subjects compared to controls, while no significant difference was noted for IL-4. IL-5 and IL-13 high CRS were associated with worse objective measures of disease severity and greater rates of revision surgery. Similar relationships were noted for both cytokines when CRSwNP patients were analyzed separately. Th2-high CRS and Th2-low CRS were then categorized using a scaled IL-5/IL-13 metric. Th2-high CRS was characterized by an increased number of subjects with nasal polyps and comorbid asthma, and worse symptom and CT scores. The Th2-associated cytokines, IL-5 and IL-13, are detectable in sinonasal mucus and their levels can be used to define Th2-high and Th2-low CRS. Identification of Th2-high and Th2-low endotypes using mucus-based biomarkers could facilitate stratification of CRS subgroups and guide personalized therapies.
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DOI：
10.2500/ajr.2008.22.3136
发表时间：
2008-03-01
期刊：
AMERICAN JOURNAL OF RHINOLOGY
影响因子：
--
作者：
Ramanathan, Murugappan, Jr.;Lee, Won-Kyung;Lane, Andrew P.
通讯作者：
Lane, Andrew P.
影响因子：
6.1
作者：
Riccio, AN;Tosca, NA;Ciprandi, G
通讯作者：
Ciprandi, G
影响因子：
2.6
作者：
Oyer, Samuel L.;Mulligan, Jennifer K.;Schlosser, Rodney J.
通讯作者：
Schlosser, Rodney J.
影响因子：
76.2
作者：
Chupp, Geoffrey L.;Bradford, Eric S.;ten Brinke, Anneke
通讯作者：
ten Brinke, Anneke
影响因子：
120.7
作者：
Bachert, Claus;Mannent, Leda;Sutherland, E. Rand
通讯作者：
Sutherland, E. Rand