Cellular senescence and senolytics: the path to the clinic.
Cellular senescence and senolytics: the path to the clinic.
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DOI：
10.1038/s41591-022-01923-y
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发表时间：
2022-08
期刊：
影响因子：
82.9
通讯作者：
Kirkland, James L.
中科院分区：
文献类型：
--
作者：
Chaib, Selim;Tchkonia, Tamar;Kirkland, James L.
相互联系和基本的老化过程似乎是导致许多疾病和疾病的根本原因。 ，由于临床前模型中的许多蛋白质，对组织功能产生有害影响。组织损伤已被证明延迟，预防或减轻多种疾病，因此发现小分子的鼻溶剂，有选择地清除感觉细胞已确保预防或治疗人类的年龄相关的策略。临床试验 - 将小分子鼻溶液和其他感应靶向干预措施转化为临床使用。
Interlinked and fundamental aging processes appear to be a root-cause contributor to many disorders and diseases. One such process is cellular senescence, which entails a state of cell cycle arrest in response to damaging stimuli. Senescent cells can arise throughout the lifespan and, if persistent, can have deleterious effects on tissue function due to the many proteins they secrete. In preclinical models, interventions targeting those senescent cells that are persistent and cause tissue damage have been shown to delay, prevent or alleviate multiple disorders. In line with this, the discovery of small-molecule senolytic drugs that selectively clear senescent cells has led to promising strategies for preventing or treating multiple diseases and age-related conditions in humans. In this Review, we outline the rationale for senescent cells as a therapeutic target for disorders across the lifespan and discuss the most promising strategies—including recent and ongoing clinical trials—for translating small-molecule senolytics and other senescence-targeting interventions into clinical use.
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影响因子：
20.8
作者：
Chini CCS;Peclat TR;Warner GM;Kashyap S;Espindola-Netto JM;de Oliveira GC;Gomez LS;Hogan KA;Tarragó MG;Puranik AS;Agorrody G;Thompson KL;Dang K;Clarke S;Childs BG;Kanamori KS;Witte MA;Vidal P;Kirkland AL;De Cecco M;Chellappa K;McReynolds MR;Jankowski C;Tchkonia T;Kirkland JL;Sedivy JM;van Deursen JM;Baker DJ;van Schooten W;Rabinowitz JD;Baur JA;Chini EN
通讯作者：
Chini EN
影响因子：
9
作者：
Afreen, Sehar;Bohler, Sheila;Erlacher, Miriam
通讯作者：
Erlacher, Miriam
影响因子：
10.5
作者：
Chien, Yuchen;Scuoppo, Claudio;Lowe, Scott W.
通讯作者：
Lowe, Scott W.
DOI：
10.1016/j.bbrc.2019.03.199
发表时间：
2019-05-28
影响因子：
3.1
作者：
Chini, Claudia;Hogan, Kelly A.;Chini, Eduardo
通讯作者：
Chini, Eduardo
影响因子：
6.2
作者：
Chandra, Abhishek;Lagnado, Anthony B.;Pignolo, Robert J.
通讯作者：
Pignolo, Robert J.