Human platelets and their capacity of binding viruses: meaning and challenges?
Human platelets and their capacity of binding viruses: meaning and challenges?
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DOI：
10.1186/s12865-015-0092-1
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发表时间：
2015-04-28
期刊：
影响因子：
3
通讯作者：
Garraud O
中科院分区：
文献类型：
--
作者：
Chabert A;Hamzeh-Cognasse H;Pozzetto B;Cognasse F;Schattner M;Gomez RM;Garraud O
血小板的首要目的是确保初级止血。除了这一作用之外，它们还被认为具有维持血管乔木的功能，最近还被认为是先天免疫细胞，主要用于检测危险信号，其中包括传染性信号。血小板表达病原体识别受体，可以感知细菌和病毒的部分。此外，一些与上皮或亚内皮分子结合的分子，以及其他与止血有关的分子，恰好能够连接病毒决定因子，使血小板能够与病毒结合，甚至被其中一些病毒感染。此外，由于血小板既表达Ig的fc受体，也表达补体受体，它们偶尔也会结合病毒-Ig或病毒-Ig-补体免疫复合物。病毒与血小板的相互作用非常复杂，病毒感染经常干扰血小板的数量和功能。通过一些病毒感染的实例，本综述旨在从病理生理和临床的角度介绍一些最重要的相互作用，这些相互作用是在人类病毒和血小板之间观察到的。
Blood platelets are first aimed at ensuring primary hemostasis. Beyond this role, they have been acknowledged as having functions in the maintenance of the vascular arborescence and, more recently, as being also innate immune cells, devoted notably to the detection of danger signals, of which infectious ones. Platelets express pathogen recognition receptors that can sense bacterial and viral moieties. Besides, several molecules that bind epithelial or sub-endothelial molecules and, so forth, are involved in hemostasis, happen to be able to ligate viral determinants, making platelets capable of either binding viruses or even to be infected by some of them. Further, as platelets express both Fc-receptors for Ig and complement receptors, they also bind occasionally virus-Ig or virus-Ig-complement immune complexes. Interplays of viruses with platelets are very complex and viral infections often interfere with platelet number and functions. Through a few instances of viral infections, the present review aims at presenting some of the most important interactions from pathophysiological and clinical points of view, which are observed between human viruses and platelets.
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