Disruption of the Blood Brain Barrier by Brain Metastases of Triple-Negative and Basal-Type Breast Cancer But Not HER2/neu-Positive Breast Cancer
Disruption of the Blood Brain Barrier by Brain Metastases of Triple-Negative and Basal-Type Breast Cancer But Not HER2/neu-Positive Breast Cancer
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DOI：
10.1002/cncr.24735
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发表时间：
2010-01-15
期刊：
影响因子：
6.2
通讯作者：
Fujiwara, Yasuhiro
中科院分区：
文献类型：
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作者：
Yonemori, Kan;Tsuta, Koji;Fujiwara, Yasuhiro
背景：一般认为脑转移瘤的血脑屏障（blood-brain barrier，BBB）受到破坏。方法：我们回顾性地进行了葡萄糖转运蛋白1（GLUT1）和乳腺癌耐药蛋白（BCRP）的免疫组织化学染色，以评估脑转移瘤切除后血脑屏障的状态。还分析了GLUT 1和/或BCRP表达与乳腺癌免疫组化特征之间的关联，如激素受体、人表皮生长因子受体2（HER2/neu）和基底型标志物（细胞角蛋白5/6，HER1）的状态。结果：该研究包括29例接受脑肿瘤切除术的乳腺癌脑转移患者。在29例患者中，分别有9例（32%）和11例（38%）患者的肿瘤内微血管中无GLUT 1和BCRP表达。8例（28%）患者GLUT1和BCRP均不表达。GLUT1与BCRP的表达显著相关（P <0.001）。GLUT1和/或BCRP的表达与HER2/neu阳性乳腺癌的脑转移呈正相关（P = 0.012），而GLUT1和/或BCRP的表达与三阴性或基底型乳腺癌的脑转移呈负相关（三阴性和基底型分别为P = 0.014和P = 0.003）。结论：三阴性或基底型乳腺癌的脑转移通常可能破坏BBB，而HER2/neu阳性乳腺癌的脑转移倾向于保留BBB。Cancer 2010; 116：302 - 8. (C)2070美国癌症协会
BACKGROUND: Generally, the blood-brain barrier (BBB) of brain metastasis was thought to be disrupted. METHODS: We retrospectively performed immunohistochemical staining for glucose transporter 1 (GLUT1) and breast cancer resistance protein (BCRP) to evaluate the status of the BBB in resected brain metastases. Associations between expression of GLUT1 and/or BCRP and the immunohistochemical profiles of breast cancers, such as the statuses of hormone receptors, human epidermal growth factor receptor 2 (HER2/neu), and a basal-type marker (cytokeratin 5/6, HER1), were also analyzed. RESULTS: The study included 29 breast cancer patients with brain metastasis who had undergone brain tumor resections. Among the 29 patients, there was no expression of GLUT1 and BCRP in the intratumor microvessels of 9 (32%) and 11 (38%) patients, respectively. There was no expression of both GLUT1 and BCRP in 8 patients (28%). The expression of GLUT1 was significantly associated with that of BCRP (P < .001). A positive correlation was observed between the expression of GLUT1 and/or BCRP and brain metastases of HER2/neu-positive breast cancer (P = .012), while a negative correlation was observed between the expression of GLUT1 and/or BCRP and brain metastases of triple negative or basal-type breast cancer (P = .014 and P = .003 for triple negative and basal-type, respectively). CONCLUSIONS: Brain metastases of triple negative or basal-type breast cancers may often disrupt the BBB, whereas brain metastases of HER2/neu-positive breast cancer tend to preserve the BBB. Cancer 2010;116:302-8.(C) 2070 American Cancer Society.