Thinning of the cerebral cortex in aging
Thinning of the cerebral cortex in aging
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DOI：
10.1093/cercor/bhh032
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发表时间：
2004-07-01
期刊：
影响因子：
3.7
通讯作者：
Fischl, B
中科院分区：
文献类型：
--
作者：
Salat, DH;Buckner, RL;Fischl, B
研究人员测量了106名年龄从18岁到93岁的非痴呆参与者的大脑皮层厚度。对于每个参与者，对结构性T-1加权磁共振成像（MRI）扫描的多次采集进行平均，以产生高分辨率、高对比度的数据集。皮质厚度估计为灰色/白色边界与外皮质表面之间的距离，从而得到跨皮质层的连续估计值。到中年时，全球变薄是明显的。男性和女性显示出相似程度的全球变薄，年轻或老年组的平均厚度没有差异。与糖尿病相关的差异是广泛的，但表现出局部萎缩和保留的拼凑。对来自独立样本的数据子集的检查产生了高度相似的与年龄相关的萎缩模式，这表明地图中的特定解剖模式是可靠的。某些结果，包括前额叶皮质明显萎缩，颞叶和海马旁皮质相对保留，与以前的研究结果一致。其他结果是出乎意料的，例如在初级运动皮质附近的额叶皮质和初级视觉皮质附近的距状皮质中发现显著萎缩。这些研究结果表明，皮质变薄发生在中年，并跨越广泛的皮质区域，包括初级皮质和联合皮质。
The thickness of the cerebral cortex was measured in 106 non-demented participants ranging in age from 18 to 93 years. For each participant, multiple acquisitions of structural T-1-weighted magnetic resonance imaging (MRI) scans were averaged to yield high-resolution, high-contrast data sets. Cortical thickness was estimated as the distance between the gray/white boundary and the outer cortical surface, resulting in a continuous estimate across the cortical mantle. Global thinning was apparent by middle age. Men and women showed a similar degree of global thinning, and did not differ in mean thickness in the younger or older groups. Age-associated differences were widespread but demonstrated a patchwork of regional atrophy and sparing. Examination of subsets of the data from independent samples produced highly similar age-associated patterns of atrophy, suggesting that the specific anatomic patterns within the maps were reliable. Certain results, including prominent atrophy of prefrontal cortex and relative sparing of temporal and parahippocampal cortex, converged with previous findings. Other results were unexpected, such as the finding of prominent atrophy in frontal cortex near primary motor cortex and calcarine cortex near primary visual cortex. These findings demonstrate that cortical thinning occurs by middle age and spans widespread cortical regions that include primary as well as association cortex.