Ginsenoside Rb1 and Rg1 improve spatial learning and increase hippocampal synaptophysin level in mice
Ginsenoside Rb1 and Rg1 improve spatial learning and increase hippocampal synaptophysin level in mice
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DOI：
10.1002/jnr.1045
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发表时间：
2001-03-15
影响因子：
4.2
通讯作者：
Jung, MW
中科院分区：
文献类型：
--
作者：
Mook-Jung, I;Hong, HS;Jung, MW
我们研究了Rb 1和Rg 1的认知增强作用。在注射（i. p.）Rb 1（1 mg/kg）或Rg 1（1 mg/kg）连续4天。与对照组相比，注射Rb 1和Rg 1的小鼠表现出增强的空间学习能力。与对照组小鼠相比，治疗组小鼠的海马体（而非额叶皮质）含有更高密度的突触标记蛋白突触素。海马脑片的电生理记录显示，Rb 1或Rg 1注射没有改变成对脉冲易化或长时程增强的幅度。我们的研究结果表明，Rb 1和Rg 1增强空间学习能力，增加海马突触密度，而不改变个别突触的可塑性。神经科学杂志Res. 63：509-515，2001. (C)2001 Wiley-Liss，Inc.
We investigated the cognition enhancing effects of ginsenoside Rb1 and Rg1. Mice were trained in a Morris water maze following injection (i.p.) of Rb1 (1 mg/kg) or Rg1 (1 mg/kg) for 4 days. Both Rb1- and Rg1-injected mice showed enhanced spatial learning compared to control animals. The hippocampus, but not the frontal cortex, of treated mice contained higher density of a synaptic marker protein, synaptophysin, compared to control mice. Electrophysiological recordings in hippocampal slices revealed that Rb1 or Rg1 injection did not change the magnitude of paired-pulse facilitation or long-term potentiation. Our results suggest that Rb1 and Rg1 enhance spatial learning ability by increasing hippocampal synaptic density without changing plasticity of individual synapses. J. Neurosci. Res. 63:509-515, 2001. (C) 2001 Wiley-Liss, Inc.