Design and manufacture of an ultra-high field ex vivo coil assembly
Design and manufacture of an ultra-high field ex vivo coil assembly
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超高场离体线圈组件的设计和制造
DOI：
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发表时间：
2012
期刊：
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通讯作者：
Loren Daniel Bridgers
中科院分区：
文献类型：
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作者：
Loren Daniel Bridgers
基于磁共振的结构分割旨在检测大脑结构的变化，这些变化可能为癫痫、精神分裂症、阅读障碍和自闭症等疾病提供令人难以置信的洞察力。体外扫描数据对于开发自动方法以检测体内这些关键变化是必要的（1）（2）。离体成像的优化需要特殊用途仪器的设计和构造。本论文介绍了用于7特斯拉MRI的32通道离体线圈组件的机械设计和构造。该装置将用于Athinoula A的研究。位于马萨诸塞州查尔斯敦的马蒂诺斯生物医学成像中心。还提出了两个独特的低成本的工具，以提高医疗器械的原型制作过程中的开发和实施：一个桌面真空铸造系统，和一个自动工具路径生成程序直接从STL文件加工。最后，开发并实现了一种用于对组织样本进行脱气的改进的方法和装置，从而提高了MRI图像质量。
Magnetic Resonance based architectonic segmentation aims to detect variations in brain architecture that may provide incredible insight into diseases such as epilepsy, schizophrenia, dyslexia, and autism. Data from ex vivo scans is necessary for the development of automatic methods to detect these critical variations in vivo (1) (2). The optimization of ex vivo imaging requires the design and construction of special purpose instrumentation. This thesis presents the mechanical design and construction of a 32 channel ex vivo coil assembly for use in a 7 tesla MRI. The unit will be used for research at the Athinoula A. Martinos Center for Biomedical Imaging in Charlestown, Massachusetts. Also presented is the development and implementation of two unique low-cost tools to enhance the medical instrument prototyping process: a desktop vacuum casting system, and an automatic tool-path generation program for machining directly from STL files. Finally, an improved method and apparatus for degassing the tissue samples is developed and implemented leading to improvements in MRI image quality.