A unique dermal dendritic cell subset that skews the immune response toward Th2.
A unique dermal dendritic cell subset that skews the immune response toward Th2.
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DOI：
10.1371/journal.pone.0073270
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Irimura T
中科院分区：
文献类型：
--
作者：
Murakami R;Denda-Nagai K;Hashimoto S;Nagai S;Hattori M;Irimura T
皮肤和引流淋巴结（LN）中的树突状细胞（DC）亚群可能引起不同的免疫应答类型。在皮肤和皮肤引流淋巴结中，发现表达巨噬细胞半乳糖型C型凝集素2（MGL 2/CD 301 b）的真皮DC亚群与迁移性朗格汉斯细胞（LC）或CD 103+真皮DC（dDC）不同。转录组分析表明，与CD 103 + dDC相比，MGL 2 + dDC中Th 1促进和/或交叉呈递相关分子的表达水平较低，并通过定量实时PCR分析得到验证。在接触性超敏反应模型中，从FITC致敏小鼠转移MGL 2 + dDC而不是CD 103 + dDC在体内诱导Th 2型免疫应答。用抗MGL 2的大鼠单克隆抗体靶向MGL 2 + dDCs有效诱导具有Th 2型特性的体液免疫应答，如通过抗体亚类所确定的。我们提出MGL 2 + dDC的性质与CD 103 + dDC的性质互补，并且使免疫应答偏向Th 2型应答。
Dendritic cell (DC) subsets in the skin and draining lymph nodes (LNs) are likely to elicit distinct immune response types. In skin and skin-draining LNs, a dermal DC subset expressing macrophage galactose-type C-type lectin 2 (MGL2/CD301b) was found distinct from migratory Langerhans cells (LCs) or CD103+ dermal DCs (dDCs). Lower expression levels of Th1-promoting and/or cross-presentation-related molecules were suggested by the transcriptome analysis and verified by the quantitative real-time PCR analysis in MGL2+ dDCs than in CD103+ dDCs. Transfer of MGL2+ dDCs but not CD103+ dDCs from FITC-sensitized mice induced a Th2-type immune response in vivo in a model of contact hypersensitivity. Targeting MGL2+ dDCs with a rat monoclonal antibody against MGL2 efficiently induced a humoral immune response with Th2-type properties, as determined by the antibody subclass. We propose that the properties of MGL2+ dDCs, are complementary to those of CD103+ dDCs and skew the immune response toward a Th2-type response.
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影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
DOI：
10.1084/jem.20071966
发表时间：
2007-12-24
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bursch LS;Wang L;Igyarto B;Kissenpfennig A;Malissen B;Kaplan DH;Hogquist KA
通讯作者：
Hogquist KA
影响因子：
4.4
作者：
Gombert, M;Dieu-Nosjean, MC;Homey, B
通讯作者：
Homey, B
影响因子：
4.4
作者：
Hoshino, Akiyoshi;Kawamura, Yuki I.;Dohi, Taeko
通讯作者：
Dohi, Taeko
影响因子：
5.5
作者：
Feili-Hariri, M;Falkner, DH;Morel, PA
通讯作者：
Morel, PA