Regional volumetric coronary blood flow measurement by digital angiography: In vivo validation
Regional volumetric coronary blood flow measurement by digital angiography: In vivo validation
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DOI：
10.1016/j.acra.2004.04.002
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发表时间：
2004-07-01
影响因子：
4.8
通讯作者：
Kassab, GS
中科院分区：
文献类型：
--
作者：
Molloi, S;Zhou, YF;Kassab, GS
基本原理和目标。众所周知，使用视觉估计来评估冠状动脉疾病和管腔狭窄的严重程度是有局限性的。在中度冠状动脉病变（30%-70%直径狭窄）的情况下尤其如此，冠状动脉造影在区分致缺血的中度冠状动脉病变和非致缺血的冠状动脉病变方面非常有限。出于这个原因，需要对狭窄严重程度进行功能性测量。本研究的目的是验证视频密度测量技术定量评估区域容量冠状动脉血流量。材料与方法。8头猪（体重25-50 kg）在左冠状动脉主动脉注射造影剂后进行冠状动脉造影。相位匹配减去图像使用视频密度测量技术量化区域冠状动脉血流。使用超音波流量探头验证了体内区域流量测量结果。在44项测量中，超声（Q(US)）和视频密度（Q(VD)）区域流量测量的相关系数为Q(VD) = 0-98 Q(US) + 0.11 mL/min （r = 0.98）。重复冠状动脉造影第一次（Q(VD1)）和第二次（Q(VD2)）测量的平均冠状动脉区域血流量的结果与Q(VD1) = 1.04 QVD2 + 0.05 mL/min （r = 0.97）相关。用猪动物模型验证了视频密度测量技术定量区域冠状动脉血流。结果证明了视频密度测量技术在体内精确测量局部冠状动脉血流的可行性和潜在效用。这项研究提供了一种血管造影方法，可以潜在地用于评估常规冠状动脉造影期间的中间冠状动脉病变。
Rationale and Objectives. There are well-known limitations to the use of visual estimation to assess the severity of coronary artery disease and luminal stenosis. This is especially true in the case of an intermediate coronary lesion (30%-70% diameter stenosis), where coronary arteriography is very limited in distinguishing ischemia-producing intermediate coronary lesions from non-ischemia-producing ones. For this reason, a functional measure of stenosis severity is desirable. The goal of this study is to validate a video densitometry technique for quantitative assessment of regional volumetric coronary blood flow.Materials and Methods. Coronary arteriography was performed in eight swine (body weight, 25-50 kg) after power injection of contrast material into the left main coronary artery. Phase-matched subtracted images were used to quantify regional coronary blood flow using a video densitometry technique. The in vivo regional flow measurements were validated using a transit time ultrasound flow probe.Results. In 44 measurements, the ultrasound (Q(US)) and video densitometry (Q(VD)) regional flow measurements were related by Q(VD) = 0-98 Q(US) + 0.11 mL/min (r = 0.98). The results of mean regional coronary blood flow measurements for repeated coronary arteriograms of the first (Q(VD1)) and second (Q(VD2)) measured flows were related by Q(VD1) = 1.04 QVD2 + 0.05 mL/min (r = 0.97).Conclusions. A video densitometry technique for quantification of regional coronary blood flow was validated using a swine animal model. The results demonstrated the feasibility and potential utility of the video densitometry technique for accurate measurement of regional coronary blood flow, in vivo. This study provides an angiographic method that can potentially be used to evaluate intermediate coronary lesions during routine coronary arteriography.