Spray-dried magnetic chitosan/Fe3O4/halloysite nanotubes/ofloxacin microspheres for sustained release of ofloxacin
Spray-dried magnetic chitosan/Fe3O4/halloysite nanotubes/ofloxacin microspheres for sustained release of ofloxacin
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DOI：
10.1039/c3ra43874k
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发表时间：
2013-10
期刊：
影响因子：
3.9
通讯作者：
Qin Wang;Junping Zhang;Aiqin Wang
中科院分区：
文献类型：
--
作者：
Qin Wang;Junping Zhang;Aiqin Wang
采用喷雾干燥法制备了一系列壳聚糖/Fe 3 O 4/埃洛石纳米管/氧氟沙星（CTS/Fe 3 O 4/HNTs/OFL）磁性微球，用于氧氟沙星的缓释。在喷雾干燥过程中，用戊二醛对壳聚糖进行原位交联。采用红外光谱、扫描电镜和热重分析对磁性微球进行了表征。对所制备的OFL磁性微球的磁性、包封率、载药量及体外缓释性能进行了评价。CTS/Fe 3 O 4/HNTs/OFL微球具有超顺磁性和快速的磁响应。与HNTs相比，Fe 3 O 4纳米粒子对微球的表面形貌有显著的影响。包封率和累积释放量与HNTs和Fe 3 O 4含量、交联密度和CTS浓度密切相关。OFL从磁性CTS/Fe 3 O 4/HNTs/OFL微球中通过反常输运释放。
A series of magnetic chitosan/Fe3O4/halloysite nanotubes/ofloxacin (CTS/Fe3O4/HNTs/OFL) microspheres was prepared by spray-drying for the sustained release of OFL. CTS was in situ crosslinked by glutaraldehyde in the spray-drying process. The magnetic microspheres were characterized by FT-IR, scanning electron microscopy and thermogravimetric analysis. The magnetic properties, encapsulation efficiency, drug loading and in vitro sustained release properties of the magnetic microspheres for OFL were also evaluated. The CTS/Fe3O4/HNTs/OFL microspheres show superparamagnetic properties and fast magnetic response. The Fe3O4 nanoparticles have a remarkable effect on the surface morphology of the microspheres compared with HNTs. The encapsulation efficiency and the cumulative release are closely related to HNTs and Fe3O4 contents, crosslinking density and CTS concentration. OFL is released from the magnetic CTS/Fe3O4/HNTs/OFL microspheres via anomalous transport.