Salivary cortisol response to awakening in chronic fatigue syndrome
Salivary cortisol response to awakening in chronic fatigue syndrome
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DOI：
10.1192/bjp.184.2.136
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发表时间：
2004-02
影响因子：
10.5
通讯作者：
A. Roberts;S. Wessely;T. Chalder;A. Papadopoulos;A. Cleare
中科院分区：
文献类型：
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作者：
A. Roberts;S. Wessely;T. Chalder;A. Papadopoulos;A. Cleare
背景慢性疲劳综合征（CFS）患者存在下丘脑-垂体-肾上腺（HPA）轴紊乱的证据越来越多。唾液皮质醇对觉醒的反应最近被描述为HPA轴对应激反应能力的非侵入性测试。该测试的结果与文献中报道的更具侵入性的动态测试密切相关;此外，它可以在自然环境中进行。目的探讨慢性疲劳综合征（CFS）患者唾液皮质醇对觉醒反应的影响。方法对56例CFS患者和35例健康志愿者分别于清醒时、清醒后10、20、30和60 min测定唾液皮质醇。结果患者对觉醒的皮质醇反应较低，以曲线下面积测量。结论CFS患者HPA轴对应激反应的自然测试显示HPA轴功能受损。
Background There is accumulating evidence of hypothalamic–pituitary–adrenal (HPA) axis disturbances in chronic fatigue syndrome (CFS). The salivary cortisol response to awakening has been described recently as a non-invasive test of the capacity of the HPA axis to respond to stress. The results of this test correlate closely with those of more invasive dynamic tests reported in the literature; furthermore, it can be undertaken in a naturalistic setting. Aims To assess the HPA axis using the salivary cortisol response to awakening in CFS. Method We measured salivary cortisol upon awakening and 10, 20, 30 and 60 min afterwards in 56 patients with CFS and 35 healthy volunteers. Results Patients had a lower cortisol response to awakening, measured by the area under the curve. Conclusions This naturalistic test of the HPA axis response to stress showed impaired HPA axis function in CFS.