Poxvirus cancer therapy.
Poxvirus cancer therapy.
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DOI：
10.2174/157489106778777592
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发表时间：
2006-11-01
影响因子：
--
通讯作者：
McFadden, Grant
中科院分区：
文献类型：
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作者：
Gilbert, Philippe-Alexandre;McFadden, Grant
尽管化疗和其他医疗技术取得了许多进展，但癌症患者通常会出现局部复发或转移性扩散。分子生物学和肿瘤免疫学的最新进展导致许多新的抗肿瘤疫苗的设计。这些方法现在使用重组病毒来治疗不同类型的癌症。从这些新的发展，创新领域正在出现：疫苗病毒治疗，病毒免疫治疗，溶瘤病毒治疗和药物病毒治疗。目前，许多病毒被用作重组载体，每种病毒都具有天然或合成的特征，可以提供治疗癌症的独特手段。痘病毒是大的双链DNA病毒，其作为重组载体提供许多有利的特征。基于痘病毒的载体由于其DNA的大尺寸和高度安全性而提供了基本上无限的遗传操作可能性。牛痘病毒，正痘病毒属的原型病毒，广泛用于根除天花，和其他痘病毒现在正在考虑和用于治疗癌症。本文将通过描述最近的专利（2000-2005年）来介绍它们作为抗癌治疗剂的应用。
Despite many advances in chemotherapy and other medical techniques, patients with cancer often develop local recurrence or metastatic spread. Recent advances in molecular biology and tumor immunology have led to the design of many new anti-tumor vaccines. Such approaches are now using recombinant viruses to treat different types of cancer. From these new developments, innovative fields are emerging: vaccine virotherapy, viral immunotherapy, oncolytic virotherapy and drug virotherapy. Many viruses are currently exploited as recombinant vectors and each offers natural or synthetic characteristics that may provide unique means to treat cancer. Poxviruses are large double stranded DNA viruses that offer many advantageous characteristics as recombinant vectors. Poxvirus-based vectors offer essentially unlimited possibilities for genetic manipulation due to the large size of their DNA and high degree of safety. Vaccinia virus, the prototype virus of the Orthopoxvirus genus that was extensively used to eradicate Smallpox, and other poxviruses are now being considered and used for the treatment of cancer. This review will cover their utilization as anti-cancer therapeutics by describing recent patents (2000-2005).