Effects of oral contraceptive therapy on the renin-angiotensin system.
Effects of oral contraceptive therapy on the renin-angiotensin system.
复制标题
口服避孕药治疗对肾素-血管紧张素系统的影响。
DOI：
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发表时间：
1971
影响因子：
5.8
通讯作者：
K. Catt
中科院分区：
文献类型：
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作者：
M. Cain;W. Walters;K. Catt
在使用雌激素-孕激素口服避孕药期间，用放射免疫法测定血液血管紧张素II水平升高到正常值的3倍。这种血管紧张素II的显著升高发生在开始治疗的5天内，在口服避孕药治疗期间持续3个月，并在停止治疗后降至正常水平。血浆肾素活性和肾素底物在治疗期间也出现类似的升高，并与血管紧张素II水平显著相关。治疗期间血浆肾素浓度显著下降，降至控制值的50%左右，且与血管紧张素II水平呈负相关。这些观察结果表明，在避孕治疗期间，雌激素诱导的血浆肾素底物和肾素活性的升高导致血管紧张素II的高循环水平，并为肾素分泌的伴随抑制提供了确凿的证据。
ABSTRACT During treatment with estrogenprogestogen oral contraceptive preparations, blood levels of angiotensin II measured by radioimmunoassay were elevated to three times the normal value. This marked rise in blood angiotensin II occurred within five days of commencing treatment, persisted during oral contraceptive therapy for three months, and fell to normal levels after cessation of treatment. Plasma renin activity and renin substrate showed similar elevations during treatment, and were significantly correlated with the levels of blood angiotensin II. Plasma renin concentration fell significantly during treatment, to about 50% of the control value, and was inversely correlated with the blood angiotensin II level. These observations demonstrate that the estrogen-induced rises in plasma renin substrate and renin activity during contraceptive therapy result in high circulating levels of angiotensin II, and provide confirmatory evidence for the concept that the concomitant suppression of renin secretion i...