The human voice areas: Spatial organization and inter-individual variability in temporal and extra-temporal cortices.
The human voice areas: Spatial organization and inter-individual variability in temporal and extra-temporal cortices.
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DOI：
10.1016/j.neuroimage.2015.06.050
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发表时间：
2015-10-01
期刊：
影响因子：
5.7
通讯作者：
Belin P
中科院分区：
文献类型：
--
作者：
Pernet CR;McAleer P;Latinus M;Gorgolewski KJ;Charest I;Bestelmeyer PE;Watson RH;Fleming D;Crabbe F;Valdes-Sosa M;Belin P
功能磁共振成像研究越来越多地检查人类听觉皮层的非主要区域的功能和特性。然而，目前还没有标准化的定位程序来可靠地识别个体之间的特定区域，例如视觉领域中可用的标准“定位器”。在这里，我们提出了一个功能磁共振成像“语音定位器”扫描，允许快速和可靠的定位语音敏感的“颞语音区”（TVA）的人类听觉皮层。我们描述了使用这种标准化定位器扫描在一个大的正常成人受试者队列中获得的结果。大多数受试者（94%）显示出沿上级颞沟/回（STS/STG）的双侧斑块对人声的反应显著大于沿着的非人声。个体激活模式虽然可重现，但在精确的解剖位置上显示出较高的个体间变异性。来自大群组的个体峰的聚类分析突出了三个双侧语音敏感性聚类，或分别沿后（TVAp）、中（TVAm）和前（TVAa）STS/STG的“语音斑块”（沿着STS/STG）。一系列颞外区域，包括双侧下前额叶皮层和杏仁核，作为大规模大脑语音网络的一部分，显示出小而可靠的语音敏感性。语音定位器扫描的刺激和MNI空间中的概率图可供下载。沿上级颞回/沟沿着的三个“语音块”。解剖位置在个体内可重复，但个体间可变。扩展的语音处理网络包括杏仁核和前额叶皮层。“语音定位器”扫描的刺激材料可供下载。
fMRI studies increasingly examine functions and properties of non-primary areas of human auditory cortex. However there is currently no standardized localization procedure to reliably identify specific areas across individuals such as the standard ‘localizers’ available in the visual domain. Here we present an fMRI ‘voice localizer’ scan allowing rapid and reliable localization of the voice-sensitive ‘temporal voice areas’ (TVA) of human auditory cortex. We describe results obtained using this standardized localizer scan in a large cohort of normal adult subjects. Most participants (94%) showed bilateral patches of significantly greater response to vocal than non-vocal sounds along the superior temporal sulcus/gyrus (STS/STG). Individual activation patterns, although reproducible, showed high inter-individual variability in precise anatomical location. Cluster analysis of individual peaks from the large cohort highlighted three bilateral clusters of voice-sensitivity, or “voice patches” along posterior (TVAp), mid (TVAm) and anterior (TVAa) STS/STG, respectively. A series of extra-temporal areas including bilateral inferior prefrontal cortex and amygdalae showed small, but reliable voice-sensitivity as part of a large-scale cerebral voice network. Stimuli for the voice localizer scan and probabilistic maps in MNI space are available for download. Three “voice patches” along human superior temporal gyrus/sulcus. Anatomical location reproducible within- but variable between-individuals. Extended voice processing network includes amygdala and prefrontal cortex. Stimulus material for “voice localizer” scan available for download.