Flexible Sensory Representations in Auditory Cortex Driven by Behavioral Relevance.
Flexible Sensory Representations in Auditory Cortex Driven by Behavioral Relevance.
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由行为相关性驱动的听觉皮层中的灵活感觉表示。
DOI：
10.1016/j.neuron.2015.10.024
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发表时间：
2015-12-02
期刊：
影响因子：
16.2
通讯作者：
Isaacson JS
中科院分区：
文献类型：
--
作者：
Kato HK;Gillet SN;Isaacson JS
动物需要有能力忽略没有后果的感官刺激，但当它们变得有用时对相同的刺激做出反应。然而，控制这种感觉处理灵活性的大脑回路尚不清楚。在这里，我们在小鼠初级听觉皮层 (A1) 中发现，每天的被动声音暴露会导致 2/3 层锥体细胞对所经历的声音的表征持续减少。这种习惯化发生在 A1 局部，涉及表达生长抑素的抑制性神经元（SOM 细胞）活性的抑制增强和选择性上调。此外，当小鼠进行声音引导行为时，锥体细胞对习惯声音的兴奋反应增强，而 SOM 细胞反应减弱。总之，我们的结果证明了 A1 感觉表征的双向调节，并表明 SOM 细胞根据刺激的行为相关性来控制皮质信息流。
Animals require the ability to ignore sensory stimuli that have no consequence, yet respond to the same stimuli when they become useful. However, the brain circuits that govern this flexibility in sensory processing are not well understood. Here we show in mouse primary auditory cortex (A1) that daily passive sound exposure causes a long-lasting reduction in representations of the experienced sound by layer 2/3 pyramidal cells. This habituation arises locally in A1 and involves an enhancement in inhibition and selective upregulation in the activity of somatostatin-expressing inhibitory neurons (SOM cells). Furthermore, when mice engage in sound-guided behavior, pyramidal cell excitatory responses to habituated sounds are enhanced while SOM cell responses are diminished. Together, our results demonstrate the bidirectional modulation of A1 sensory representations and suggest that SOM cells gate cortical information flow based on the behavioral relevance of the stimulus.