Metastatic lesions involving the cerebellopontine angle.
Metastatic lesions involving the cerebellopontine angle.
复制标题
转移性病变累及桥小脑角。
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
J. Jinkins
中科院分区：
文献类型：
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作者：
William;Yuh;Nina A. May r;Timoth y M. Koc;Jack H. Simo;Kev in L. Nelson;J. Zyroff;J. Jinkins
目的
探讨桥小脑角转移瘤的临床和MR表现，以有助于与桥小脑角良性病变的鉴别。
方法
回顾性分析了14例经临床/影像学（7例）或病理（7例）诊断为CPA转移的患者的临床和MR表现。
结果
有用的临床结果包括急性发作和快速进展的颅神经症状，特别是第7和/或第8颅神经缺损（92.9%）。颅神经症状多为单侧（50%），多累及颅神经（64.3%）。磁共振检查结果显示疾病的范围比临床表现更广泛，100%的患者有多个颅神经受累，85.7%为双侧。有用的MR结果包括小的和/或双侧CPA增强病变，在增强前MR上与脑实质相对等信号，以及多发和/或双侧颅神经和/或软脑膜病变的相关结果。
结论
这些相关的研究结果表明，脑脊液传播和/或软脑膜延伸可能是一个重要的途径转移蔓延到CPA。因为CPA转移可能是最初的或唯一的转移部位，并且可能发生在恶性肿瘤的最初诊断后许多年，所以具有临床相关性的MR表现不仅有助于CPA转移的检测，而且有助于将其与更常见的良性CPA肿瘤相鉴别。
PURPOSE
To evaluate the clinical and MR findings of metastatic lesions involving the cerebellopontine angle (CPA), which may be useful in differentiating them from the more commonly occurring benign CPA lesions.
METHODS
Clinical and MR findings of 14 patients with clinical/radiologic (seven) or pathologic (seven) diagnoses of CPA metastasis were retrospectively reviewed.
RESULTS
Useful clinical findings included acute onset and rapid progression of cranial nerve symptoms, especially 7th and/or 8th cranial nerve deficits (92.9%). Cranial nerve symptoms could be unilateral (50%) and frequently involved multiple cranial nerves (64.3%). MR findings showed significantly more extensive disease than suggested by clinical presentation, with 100% of patients having multiple cranial nerve involvement and 85.7% bilateral. Useful MR findings included small and/or bilateral CPA-enhancing lesions with relative isointensity to brain parenchyma on precontrast MR, with associated findings of multiple and/or bilateral cranial nerve and/or leptomeningeal lesions.
CONCLUSIONS
These associated findings suggest that cerebrospinal fluid dissemination and/or leptomeningeal extension may be an important pathway for metastatic spread to the CPA. Because the CPA metastasis may be the initial or only site of metastasis, and may occur many years after the initial diagnosis of malignancy, MR findings with clinical correlation are not only useful for the detection of CPA metastases, but also for their differentiation from the more common benign CPA tumors.