Serum Albumin Levels on Admission Are Associated With Angiographic No-Reflow After Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction
Serum Albumin Levels on Admission Are Associated With Angiographic No-Reflow After Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction
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DOI：
10.1177/0003319714526035
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发表时间：
2015-03-01
期刊：
影响因子：
2.8
通讯作者：
Cay, Serkan
中科院分区：
文献类型：
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作者：
Kurtul, Alparslan;Ocek, Adil Hakan;Cay, Serkan
低血清白蛋白(SA)水平与心血管死亡率增加有关。我们调查了基线SA水平是否与直接经皮冠状动脉介入治疗(PPCI)后无复流有关。共有536名患者(年龄60岁+/-13岁，其中74%为男性)接受了经皮冠状动脉介入治疗。将患者分为无复流组和正常复流组。无复流定义为心肌梗死溶栓2流。无复流组入院时SA水平显著低于正常复流组(3.55+/-0.44比4.01+/-0.32 mg/dL，P<；.001)。无复流组高敏C反应蛋白(HsCRP)、肌酐、肌酸激酶同工酶和肌钙蛋白T显著高于无复流组，而血红蛋白和左心室射血分数(LVEF)显著低于无复流组。在多变量分析中，SA水平仍然是血管造影术无复流的独立预测因子(优势比0.114，95%可信区间0.032-0.405，P=.001)，以及左心室射血分数、超敏C反应蛋白和基线罪犯动脉开通。入院SA水平是pPCI术后无复流的独立预测因子。
Low serum albumin (SA) levels are associated with increased cardiovascular mortality. We investigated whether baseline SA levels are associated with no-reflow following primary percutaneous coronary intervention (pPCI). A total of 536 patients (aged 60 +/- 13 years; 74% men) who underwent pPCI were enrolled. The patients were divided into 2 groups: no-reflow and normal-reflow. No-reflow was defined as thrombolysis in myocardial infarction 2 flow. Admission SA levels were significantly lower in the no-reflow group than in the normal-reflow group (3.55 +/- 0.44 vs 4.01 +/- 0.32 mg/dL, P < .001). Also, high-sensitivity C-reactive protein (hsCRP), creatinine, creatine kinase myocardial band isoenzyme, and troponin T were significantly higher while hemoglobin and left ventricular ejection fraction (LVEF) were significantly lower in the no-reflow group. In multivariate analysis, SA level remained an independent predictor of angiographic no-reflow (odds ratio 0.114, 95% confidence interval 0.032-0.405, P = .001) together with LVEF, hsCRP, and baseline culprit artery patency. Admission SA level was an independent predictor of no-reflow after pPCI.