The Human Gut Virome in Hypertension
The Human Gut Virome in Hypertension
复制标题
高血压中的人类肠道病毒组
DOI：
10.3389/fmicb.2018.03150
复制
发表时间：
2018-12-19
影响因子：
5.2
通讯作者：
Ning, Kang
中科院分区：
文献类型：
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作者：
Han, Maozhen;Yang, Pengshuo;Ning, Kang
目的：先前的研究报道肠道微生物组与高血压的发生具有重要联系。尽管以前的研究主要集中在肠道细菌与高血压的联系上，但人们对肠道病毒与高血压的联系以及高血压的发展知之甚少，这很大程度上是由于缺乏用于此类研究的数据挖掘工具。在这项工作中，我们分析了 196 个与高血压相关的粪便宏基因组数据，旨在分析肠道病毒组并将肠道病毒组与高血压前期和高血压联系起来。设计：在这里，我们应用了一种统计上合理的方法来挖掘肠道病毒组数据并将肠道病毒组与高血压联系起来。我们对 196 个样本的病毒组成和细菌组成进行了表征，确定了每个样本的病毒类型，并将肠道病毒组与高血压联系起来。结果：我们将这 196 个粪便样本分为两种病毒类型，并选择了 32 种病毒作为这些组的生物标志物。我们发现，在区分健康样本和高血压前期样本以及高血压样本时，病毒比细菌具有更高的分辨率和辨别能力。此外，对于连接病毒和细菌的共现网络，我们发现从健康人到高血压前期人群再到高血压患者，病毒-细菌的联系越来越普遍。结论：总的来说，我们的结果充分表明了人类肠道病毒组与高血压之间的联系，并有助于为高血压的早期诊断提供微生物解决方案。
Objectives: Previous studies have reported that the gut microbiome has an important link with the development of hypertension. Though previous researches have focused on the links of gut bacteria with hypertension, little has been known about the linkage of gut viruses to hypertension and the development of hypertension, largely due to the lack of data mining tools for such investigation. In this work, we have analyzed 196 fecal metagenomic data related to hypertension aiming to profile the gut virome and link the gut virome to pre-hypertension and hypertension.Design: Here, we have applied a statistically sound method for mining of gut virome data and linking gut virome to hypertension. We characterized the viral composition and bacterial composition of 196 samples, identified the viral-type of each sample and linked gut virome to hypertension.Results: We stratified these 196 fecal samples into two viral-types and selected 32 viruses as the biomarkers for these groups. We found that viruses could have a superior resolution and discrimination power than bacteria for differentiation of healthy samples and pre-hypertension samples, as well as hypertension samples. Moreover, as to the co-occurrence networks linking viruses and bacteria, we found increasingly pervasive virus-bacteria linkages from healthy people to pre-hypertension people to hypertension patients.Conclusion: Overall, our results have shown ample indications of the link between human gut virome and hypertension, and could help provide microbial solutions toward early diagnoses of hypertension.