An ultrastructural analysis of the vascular damage in the lethal and sublethal Forssman reaction in the guinea-pig.
An ultrastructural analysis of the vascular damage in the lethal and sublethal Forssman reaction in the guinea-pig.
复制标题
豚鼠致死和亚致死福斯曼反应中血管损伤的超微结构分析。
DOI：
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发表时间：
1985
影响因子：
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通讯作者：
A. White
中科院分区：
文献类型：
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作者：
J. Baker;G. Bullock;K. Butler;I. Williamson;A. White
补体系统和血小板在豚鼠亚致死福斯曼反应中的参与已经与肺血管内皮细胞中观察到的超微结构变化一起进行了研究。注意到的主要超微结构变化是内皮肿胀。这种情况在血小板减少的动物或补体缺失的动物中没有发生，表明血小板和补体途径在该反应中的重要性。血小板抑制剂磺吡酮或阿司匹林对亚致死反应中的内皮肿胀没有影响。在致死反应中，内皮细胞损伤程度更为严重，包括细胞膜损伤、提升、坏死，最后暴露基底膜。这种损害仅发生在具有完整补体级联的动物中。
The involvement of the complement system and platelets in the sublethal Forssman reaction in the guinea pig has been studied together with the ultrastructural changes observed in the endothelial cells of the pulmonary vasculature. The main ultrastructural change noted was swelling of the endothelium. This did not occur in thrombocytopenic animals or in decomplemented animals, indicating the importance of both platelets and the complement pathways in this reaction. The platelet inhibitors sulphinpyrazone or aspirin had no effect on endothelial swelling in the sublethal reaction. In the lethal reaction the degree of endothelial cell damage was more severe and included lesions in the cell membrane, lifting, necrosis and finally exposure of the basement membrane. This damage only occurred in animals with an intact complement cascade.