Collagen VI regulates peripheral nerve myelination and function
Collagen VI regulates peripheral nerve myelination and function
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DOI：
10.1096/fj.13-239533
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发表时间：
2014-03-01
期刊：
影响因子：
4.8
通讯作者：
Bonaldo, Paolo
中科院分区：
文献类型：
--
作者：
Chen, Peiwen;Cescon, Matilde;Bonaldo, Paolo
胶原VI是一种细胞外基质蛋白，广泛分布于多种组织中。尽管Col6a1由施万细胞表达，但VI胶原在周围神经系统（PNS）中的作用尚不清楚。在这里，我们表明，雪旺细胞，而不是轴突，有助于VI型胶原沉积在周围神经。通过使用Col6a1缺失小鼠，其中胶原VI沉积受损，我们证明缺乏胶原VI导致髓鞘厚度增加（P
Collagen VI is an extracellular matrix protein with broad distribution in several tissues. Although Col6a1 is expressed by Schwann cells, the role of collagen VI in the peripheral nervous system (PNS) is yet unknown. Here we show that Schwann cells, but not axons, contribute to collagen VI deposition in peripheral nerves. By using Col6a1-null mice, in which collagen VI deposition is compromised, we demonstrate that lack of collagen VI leads to increased myelin thickness (P