Vascular-metabolic and GABAergic Inhibitory Correlates of Neural Variability Modulation. A Combined fMRI and PET Study
Vascular-metabolic and GABAergic Inhibitory Correlates of Neural Variability Modulation. A Combined fMRI and PET Study
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神经变异调节的血管代谢和 GABA 能抑制相关性。
DOI：
10.1016/j.neuroscience.2018.02.041
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发表时间：
2018-05
期刊：
影响因子：
3.3
通讯作者：
Lane Timothy J
中科院分区：
文献类型：
--
作者：
Qin Pengmin;Duncan Niall W;Chen David Yen Ting;Chen Chi Jen;Huang Li Kai;Huang Zirui;Lin Chien Yuan E;Wiebking Christine;Yang Che Ming;Northoff Georg;Lane Timothy J
神经活动每时每刻都在不断变化。这种时间变异性（TV）已被强调为在认知中发挥基本作用的功能特定的大脑特性。我们试图研究两种基本行为状态之间的TV变化所涉及的机制，即在活体人类中睁眼（EO）或闭眼（EC）。为此，我们在一组健康参与者（n= 15）中采集了BOLD fMRI、ASL和[18 F]-氟脱氧葡萄糖PET，在另一组（n= 19）中采集了沿着BOLD fMRI和[18 F]-氟马西尼PET。聚焦于枕叶皮质中的EO与EC敏感区域（在独立样本中识别），我们表明，与EC相比，TV在EO条件下受到限制。这种减少与能量消耗的增加和区域GABAA受体密度相关。这表明行为状态对TV的调节涉及总体神经活动的增加，这与除任何兴奋性变化外的GABA能抑制作用的增加有关。这些发现有助于我们理解人类大脑活动变异及其控制的机制。
Neural activity varies continually from moment to moment. Such temporal variability (TV) has been highlighted as a functionally specific brain property playing a fundamental role in cognition. We sought to investigate the mechanisms involved in TV changes between two basic behavioral states, namely having the eyes open (EO) or eyes closed (EC)in vivoin humans. To these ends we acquired BOLD fMRI, ASL, and [18F]-fluoro-deoxyglucose PET in a group of healthy participants (n= 15), along with BOLD fMRI and [18F]-flumazenil PET in a separate group (n= 19). Focusing on an EO- vs EC-sensitive region in the occipital cortex (identified in an independent sample), we show that TV is constrained in the EO condition compared to EC. This reduction is correlated with an increase in energy consumption and with regional GABAAreceptor density. This suggests that the modulation of TV by behavioral state involves an increase in overall neural activity that is related to an increased effect from GABAergic inhibition in addition to any excitatory changes. These findings contribute to our understanding of the mechanisms underlying activity variability in the human brain and its control.
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影响因子：
3.7
作者：
Zou Q;Yuan BK;Gu H;Liu D;Wang DJ;Gao JH;Yang Y;Zang YF
通讯作者：
Zang YF
影响因子：
5.7
作者：
Bianciardi M;Fukunaga M;van Gelderen P;Horovitz SG;de Zwart JA;Duyn JH
通讯作者：
Duyn JH
影响因子：
4.3
作者：
Howarth C
通讯作者：
Howarth C
功能连接和局部脑血流的耦合揭示了人脑网络枢纽的生理基础
DOI：
10.1073/pnas.1214900110
发表时间：
2013-01-29
影响因子：
11.1
作者：
Liang, Xia;Zou, Qihong;Yang, Yihong
通讯作者：
Yang, Yihong
影响因子：
4.3
作者：
Galow LV;Schneider J;Lewen A;Ta TT;Papageorgiou IE;Kann O
通讯作者：
Kann O