DNase-1 Treatment Exerts Protective Effects in Neurogenic Pulmonary Edema via Regulating the Neutrophil Extracellular Traps after Subarachnoid Hemorrhage in Mice.
DNase-1 Treatment Exerts Protective Effects in Neurogenic Pulmonary Edema via Regulating the Neutrophil Extracellular Traps after Subarachnoid Hemorrhage in Mice.
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DOI：
10.3390/jcm11154349
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发表时间：
2022-07-27
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
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据报道，中性粒细胞胞外陷阱（NET）涉及炎症、凝血和细胞死亡。急性肺损伤也被认为与 NET 有关。脱氧核糖核酸酶 I (DNase-1) 是一种用于呼吸系统的临床药物，据报道可以降解游离 DNA (cfDNA)，而游离 DNA 是 NET 的主要成分。在此，我们进行了研究以阐明 DNase-1 在 SAH 后 NPE 中的治疗价值。在此模型中，我们发现 DNase-1 治疗显着减少了肺水、中性粒细胞浸润和炎症。此外，DNase-1 抑制巨噬细胞的 NET 和促炎亚型转变。此外，中性粒细胞的消耗也验证了NETs在NPE中的作用。我们的结果表明DNase-1有潜力有效缓解SAH后的NPE，并成为SAH后使用的临床药物。
It has been reported that neutrophil extracellular traps (NETs) involve inflammation, coagulation and cell death. Acute lung injury is also considered to be connected with NETs. Deoxyribonuclease I (DNase-1), a clinical medication for the respiratory system, has been reported to degrade cell-free DNA (cfDNA), which is the main component of NETs. Herein, we did research to clarify the therapeutic value of DNase-1 in NPE after SAH. In this model, we found that the treatment of DNase-1 remarkably decreased lung water, neutrophilic infiltration and inflammation. In addition, DNase-1 inhibited the NETs and proinflammatory subtype transition of the macrophages. Moreover, the depletion of neutrophil also verified the role of NETs in NPE. Our results suggest that DNase-1 has the potential to effectively relieve the NPE after SAH and to be a clinical drug for use after SAH.
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影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
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