Administration of haloperidol and risperidone after neurobehavioral testing hinders the recovery of traumatic brain injury-induced deficits
Administration of haloperidol and risperidone after neurobehavioral testing hinders the recovery of traumatic brain injury-induced deficits
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DOI：
10.1016/j.lfs.2008.08.007
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发表时间：
2008-10-24
期刊：
影响因子：
6.1
通讯作者：
Kline, Anthony E.
中科院分区：
文献类型：
--
作者：
Hoffman, Ann N.;Cheng, Jeffrey P.;Kline, Anthony E.
目的：激越和攻击是创伤性脑损伤常见的行为后遗症。这些症状的处理对于有效的患者护理至关重要，因此，尽管这种方法对脑外伤后功能结果的益处和风险尚不清楚，但仍需常规应用抗精神病药物。我们小组最近的一项研究表明，氟哌啶醇和利培酮在测试前给药都会损害康复。然而，这一结果可能被药物诱导的镇静所混淆。主要方法：54只异氟醚麻醉的大鼠接受皮质撞击或假损伤，然后随机分为3组，分别给予氟哌啶醇(0.5 mg/kg)、利培酮(0.45 NNG/kg)或溶剂(1.0mL/kg)。治疗开始于术后24小时，并给予(Ip)。此后的19天内每天如此。分别于术后第1~5天和14~19天进行运动功能和认知功能评定。3周后对海马CA(1)/CA(3)神经元和皮质损伤体积进行量化。主要发现：只有利培酮延缓了运动恢复，但两种抗精神病药都损害了相对于交通工具的空间学习(p
Aims: Agitation and aggression are common behavioral sequelae of traumatic brain injury (TBI). The management of these symptoms is critical for effective patient care and therefore antipsychotics are routinely administered even though the benefits vs. risks of this approach on functional outcome after TBI are unclear. A recent study from our group revealed that both haloperidol and risperidone impaired recovery when administered prior to testing. However, the results may have been confounded by drug-induced sedation. Hence, the current study reevaluated the behavioral effects of haloperidol and risperidone when provided after daily testing, thus circumventing the potential sedative effect.Main methods: Fifty-four isoflurane-anesthetized mate rats received a cortical impact or sham injury and then were randomly assigned to three TBI and three sham groups that received haloperidol (0.5 mg/kg), risperidone (0.45 nng/kg), or vehicle (1.0 mL/kg). Treatments began 24 h after surgery and were administered (i.p.) every day thereafter for 19 days. Motor and cognitive function was assessed on post-operative days 1-5 and 14-19, respectively. Hippocampal CA(1)/CA(3) neurons and cortical lesion volume were quantified at 3 weeks.Key findings: Only risperidone delayed motor recovery, but both antipsychotics impaired spatial learning relative to vehicle (p