Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida
Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida
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Hypserpa nitida 的两种新生物碱和活性抗乙型肝炎病毒成分
DOI：
10.1016/j.bmcl.2007.08.027
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发表时间：
2007-10-01
影响因子：
2.7
通讯作者：
Chen, Ji-jun
中科院分区：
文献类型：
--
作者：
Cheng, Pi;Ma, Yun-bao;Chen, Ji-jun
分离得到2个新的生物碱，分别为川参碱A、B(1，11)和11个已知化合物，分别为酚甜素(2)、乌头碱(3)、乌头碱(4)、十氯乌头碱(5)、蝙蝠葛碱(6)、蝙蝠葛碱(7)、原乌头菜碱(8)、千金藤碱(9)、S网状碱(10)、木兰花碱(12)和月桂花碱(13)。(北豆科)，并通过光谱分析进行了化学鉴定。用HBVG2.2.15细胞株对分离得到的生物碱进行体外抗乙肝病毒活性评价。最有效的化合物蝙蝠葛碱(7)对Hep G2.2.15细胞株的乙肝病毒表面抗原(HBs)分泌的IC50值为0.450 mM(SI=4.13)。(C)2007爱思唯尔有限公司。保留所有权利。
Two new alkaloids, hypserpanines A and B (1, 11), together with eleven known compounds, phenolbetain (2), acutumine (3), acutumidine (4), dechloroacutumine (5), dauricumine (6), dauricumidine (7), pronuciferine (8), glaziovine (9), S-reticuline (10), magnoflorine (12) and laurifoline(13), were isolated from Hypserpa nitida Miers. (Menispermaccae) and chemically elucidated through spectral analyses. All the isolated alkaloids were evaluated for their anti-HBV activities in vitro using the HBV transfected Hep G2.2.15 cell line. The most active compound, dauricumidine (7), exhibited an IC50 value of 0.450 mM (SI = 4.13) on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line. (C) 2007 Elsevier Ltd. All rights reserved.