Small molecular nanomedicines made from a camptothecin dimer containing a disulfide bond
Small molecular nanomedicines made from a camptothecin dimer containing a disulfide bond
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由含有二硫键的喜树碱二聚体制成的小分子纳米药物
DOI：
10.1039/c5ra18586f
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发表时间：
2015-01-01
期刊：
影响因子：
3.9
通讯作者：
Jing, Xiabin
中科院分区：
文献类型：
--
作者：
Pei, Qing;Hu, Xiuli;Jing, Xiabin
小分子喜树碱（CPT）二聚体可以在水溶液中自组装成稳定的纳米颗粒，并通过 TEM 和 DLS 进行了表征。共聚焦激光扫描显微镜显示，这些纳米药物可以被癌细胞内化，并且对 HeLa 和 HepG2 细胞具有高细胞增殖抑制作用，IC50 值低，并对 HeLa 细胞具有还原反应性细胞毒性。 CPT-NPs可行的组装方法和优异的性能为探索用于癌症治疗的新型纳米药物提供了另一种方法。
A small molecular camptothecin (CPT) dimer could self-assemble into stable nanoparticles in aqueous solution, which was characterized by TEM and DLS. These nanomedicines could be internalized by cancer cells as revealed by confocal laser scanning microscopy, and indicated high cellular proliferation inhibition toward HeLa and HepG2 cells with low IC50 values and reduction-responsive cytotoxicity towards HeLa cells. The feasible assembly method and outstanding properties of CPT–NPs provide an alternative approach for exploring new nanomedicines for cancer therapy.