TRPs in Ovarian Serous Cystadenocarcinoma: The Expression Patterns, Prognostic Roles, and Potential Therapeutic Targets.
TRPs in Ovarian Serous Cystadenocarcinoma: The Expression Patterns, Prognostic Roles, and Potential Therapeutic Targets.
复制标题
卵巢浆液性囊腺癌中的 TRP：表达模式、预后作用和潜在治疗靶点
DOI：
10.3389/fmolb.2022.915409
复制
发表时间：
2022
影响因子：
5
通讯作者：
中科院分区：
文献类型：
--
作者：
卵巢癌（通常为卵巢浆液性囊腺癌或OV）是女性癌症相关死亡的第五大原因，全球每年报告的死亡人数超过184，000人，并且是一种高度恶性的癌症。然而，其发病机制尚不清楚。缺乏预后和诊断生物标志物是临床诊断和治疗的主要限制。瞬时受体电位（TRP）通道在肿瘤的发生、发展中起重要作用，可能成为OV治疗的靶点。在我们的研究中，我们使用生物信息学方法来研究TRP家族在OV患者中的潜在作用和功能。差异表达分析显示，TRPC 7、TRPV 4等TRP家族成员在肿瘤组织和正常组织中的表达存在显著差异。通过生存分析，筛选出TRPC 7、TRPV 4、TRPM（2，4，8）的高表达与患者的预后呈负相关。TRPM 3的低表达与预后呈负相关。考克斯回归分析进一步表明TRPV 4是OV最可能的治疗靶点。最后，我们进行了mRNA表达分析、功能富集分析和免疫浸润分析，以证实TRPV4是OV最有说服力的治疗靶点。
Ovarian cancer (usually ovarian serous cystadenocarcinoma, or OV) is the fifth leading cause of cancer-related deaths in women, with more than 184,000 deaths reported worldwide annually, and is a highly malignant carcinoma. However, the mechanism of etiology remains unclear. The lack of prognostic and diagnostic biomarkers is a main limitation for clinical diagnosis and treatment. The transient receptor potential (TRP) channels play essential roles in the occurrence and development of cancers which may have the potential as a therapeutic target for OV. In our study, we used bioinformatic methods to study the potential effect and function of the TRP family in patients with OV. Differential expression analysis showed that the expression of TRPC7, TRPV4, and other TRP family members was significantly different between tumor and normal tissues. Through survival analysis, we screened out that the high expression of TRPC7, TRPV4, and TRPM (2,4,8) was negatively correlated with the prognosis of patients. In contrast, the low expression of TRPM3 was negatively associated with the prognosis. Cox regression analysis further indicated that TRPV4 was OV’s most likely therapeutic target. Finally, we conducted mRNA expression analysis, functional enrichment analysis, and immune infiltration analysis to confirm that TRPV4 was the most convincing therapeutic target of OV.
登录
查看更多内容
影响因子：
16.6
作者：
Grosche S;Marenholz I;Esparza-Gordillo J;Arnau-Soler A;Pairo-Castineira E;Rüschendorf F;Ahluwalia TS;Almqvist C;Arnold A;Australian Asthma Genetics Consortium (AAGC);Baurecht H;Bisgaard H;Bønnelykke K;Brown SJ;Bustamante M;Curtin JA;Custovic A;Dharmage SC;Esplugues A;Falchi M;Fernandez-Orth D;Ferreira MAR;Franke A;Gerdes S;Gieger C;Hakonarson H;Holt PG;Homuth G;Hubner N;Hysi PG;Jarvelin MR;Karlsson R;Koppelman GH;Lau S;Lutz M;Magnusson PKE;Marks GB;Müller-Nurasyid M;Nöthen MM;Paternoster L;Pennell CE;Peters A;Rawlik K;Robertson CF;Rodriguez E;Sebert S;Simpson A;Sleiman PMA;Standl M;Stölzl D;Strauch K;Szwajda A;Tenesa A;Thompson PJ;Ullemar V;Visconti A;Vonk JM;Wang CA;Weidinger S;Wielscher M;Worth CL;Xu CJ;Lee YA
通讯作者：
Lee YA
Lynx1在卵巢浆液性囊这内癌中的表达增加预测预后不良。
影响因子：
--
作者：
Liu H;Wang A;Ma Y
通讯作者：
Ma Y
影响因子：
12.3
作者：
Li B;Severson E;Pignon JC;Zhao H;Li T;Novak J;Jiang P;Shen H;Aster JC;Rodig S;Signoretti S;Liu JS;Liu XS
通讯作者：
Liu XS
影响因子：
158.5
作者：
Burger, Robert A.;Brady, Mark F.;Liang, Sharon X.
通讯作者：
Liang, Sharon X.
影响因子：
10.9
作者：
Li, Yong;Hodge, Johnie;Fan, Daping
通讯作者：
Fan, Daping