Interactions mediating bacterial translocation in the immature intestine
Interactions mediating bacterial translocation in the immature intestine
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DOI：
10.1093/jn/130.2.432s
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发表时间：
2000-02-01
影响因子：
4.2
通讯作者：
Duffy, LC
中科院分区：
文献类型：
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作者：
Duffy, LC
肠毒力细菌和毒素从肠腔经粘膜进入肠系膜淋巴结（MLN）引起的全身性疾病进行审查，特别关注早产儿肠道发育中的细菌相互作用。很少观察到厌氧细菌移位到MLN，已经测试了双歧杆菌菌株在培养物中粘附肠细胞样Caco-2细胞的能力。我们在各种体外和体内模型中研究了粘附的人双歧杆菌菌株对许多致龋细菌（大肠杆菌0157;鼠伤寒沙门氏菌）和病毒（小鼠和恒河猴轮状病毒）的定殖的抑制作用。人类母乳含有丰富的生物活性物质（免疫，营养），通过抑制细菌过度生长和BT提供保护作用，刺激有益的厌氧微生物菌群（乳杆菌，双歧杆菌）的新双歧杆菌疗法是研究疾病治疗中对抗BT的有希望的途径。
Systemic disease caused by transmucosal passage of enterovirulent bacteria and toxins from the gut lumen into the mesenteric lymph nodes (MLN) is reviewed, with particular concern for bacterial interactions in the developing gut of premature newborns. Anaerobic bacteria are rarely observed to translocate to the MLN, Bifidobacterial strains have been tested for their abilities to adhere to enterocyte-like Caco-2 cells in culture. We have investigated the inhibitory effect of adherent human bifidobacterial strains against colonization by a number of diarrheagenic bacteria (Escherichia coli 0157; Salmonella typhimurium) and viruses (murine and rhesus rotavirus), in various in vitro and in vivo models, The phagocytic cell (macrophage) may be a key factor in bacterial translocation (BT). Human breast milk contains abundant bioactive substances (immunologic, nutritional) that provide protective effects through inhibition of bacterial overgrowth and BT, New biotherapeutic therapies that stimulate beneficial anaerobic microflora (Lactobacillus, Bifidobacterium) are promising avenues of research to combat BT in disease treatment.