Cyclodextrin-based side-chain polyrotaxane with unidirectional inclusion in aqueous media.
Cyclodextrin-based side-chain polyrotaxane with unidirectional inclusion in aqueous media.
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DOI：
10.1002/anie.200601081
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发表时间：
2006-07
影响因子：
--
通讯作者：
Itsuro Tomatsu;A. Hashidzume;A. Harada
中科院分区：
文献类型：
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作者：
Itsuro Tomatsu;A. Hashidzume;A. Harada
最近，聚轮烷从纳米技术应用的角度吸引了研究人员的极大兴趣。[1]特别是，由简单组分组成的定义明确的聚轮烷对于构建更复杂的分子机器变得越来越重要。有许多用于制备聚轮烷的设计和策略。[2]在这些方法中，侧链聚轮烷是最简单的结构之一，但除了Ritter和同事的那些之外，只有少数含有环糊精（CD）的侧链聚轮烷的例子。[4]Ritter [4]的大量研究表明，侧链聚轮烷主要在有机介质中由甲基化β-CD和各种聚合物成功合成。在过去的十年中，我们一直在研究环糊精与连接在水溶性聚合物上的聚合物侧链的相互作用。[5]在此，我们报告了一个在水介质中成功构建基于CD的侧链聚轮烷的实例，其中CD包括优先来自具有仲羟基官能团的侧的聚合物侧链，通过使用简单组分α-CD和疏水改性的聚（丙烯酸）（pAA）的组合。
Recently, polyrotaxanes have attracted much interest from researchers from the viewpoint of nanotechnological applications.[1] In particular, well-defined polyrotaxanes that consist of simple components are becoming important for the construction of more sophisticated molecular machines. There are a number of designs and strategies for the preparation of polyrotaxanes.[2] Among these approaches, the side-chain polyrotaxane is one of the simplest architectures, but there are only a few examples of side-chain polyrotaxanes that contain cyclodextrin (CD),[3] apart from those of Ritter and co-workers.[4] Extensive studies by Ritter [4] demonstrated the successful synthesis of side-chain polyrotaxanes primarily in organic media from methylated β-CD and various polymers.Over the past decade, we have been studying the interaction of cyclodextrins with polymer side chains attached to water-soluble polymers.[5] Herein, we report an example of the successful construction of CD-based side-chain polyrotaxanes in aqueous media, in which CD includes polymer side chains preferentially from the side with the secondary hydroxy functionality, by using a combination of simple components, α-CD and hydrophobically modified poly-(acrylic acid)(pAA).