Gingival Crevicular Fluid and Plasma Acute-Phase Cytokine Levels in Different Periodontal Diseases
Gingival Crevicular Fluid and Plasma Acute-Phase Cytokine Levels in Different Periodontal Diseases
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DOI：
10.1902/jop.2012.110616
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发表时间：
2012-10-01
影响因子：
4.3
通讯作者：
Emingil, Gulnur
中科院分区：
文献类型：
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作者：
Becerik, Sema;Ozturk, Veil Ozgen;Emingil, Gulnur
背景资料：本研究的目的是探讨龈沟液（GCF）和血浆急性时相细胞因子，白细胞介素-I β结果：牙周炎患者血清IL-1 β、IL-6、IL-11、OSM、LIF水平均高于正常对照组，差异有统计学意义（P < 0. 05）。20例慢性牙周炎（CP），20例全身侵袭性牙周炎（GAgP），20例牙龈炎，20例健康（H）。记录探诊深度、临床附着水平、斑块指数和乳头出血指数。采用酶联免疫吸附法检测血浆和GCF中IL-1 β、IL-6、IL-11、OSM和LIF水平。结果：CP组和GAgP组GCF中IL-1 β、IL-6和IL-11水平显著高于H组（P
Background: The aim of the present study is to investigate gingival crevicular fluid (GCF) and plasma acute-phase cytokines, interleukin-I beta (IL-1 beta), interleukin-6 (IL-6), interleukin-11 (IL-11), oncostatin M (OSM), and leukemia inhibitory factor (LIF) levels in patients with different periodontal diseases.Methods: Eighty individuals were included in this study; 20 with chronic periodontitis (CP), 20 with generalized aggressive periodontitis (GAgP), 20 with gingivitis, and 20 classified as healthy (H). Probing depth, clinical attachment level, plaque index, and papilla bleeding index were recorded. Plasma and GCF IL-1 beta, IL-6, IL-11, OSM, and LIF levels were analyzed by enzyme-linked immunosorbent assay.Results: CP and GAgP groups had significantly higher GCF IL-1 beta, IL-6, and IL-11 levels when compared with the H group (P