Parental Separation and Offspring Alcohol Involvement: Findings from Offspring of Alcoholic and Drug Dependent Twin Fathers
Parental Separation and Offspring Alcohol Involvement: Findings from Offspring of Alcoholic and Drug Dependent Twin Fathers
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DOI：
10.1111/acer.12766
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发表时间：
2015-07-01
影响因子：
3.2
通讯作者：
Bucholz, Kathleen K.
中科院分区：
文献类型：
--
作者：
Grant, Julia D.;Waldron, Mary;Bucholz, Kathleen K.
背景我们检查了童年时期父母分居与后代酗酒之间的关联，并调整了父母酗酒 (AD) 和大麻/其他非法药物依赖 (DD) 特有的遗传和环境风险。 方法样本由来自越南时代双胞胎 (VET) 登记处的 1,828 名男性双胞胎后代组成，他们完成了电话诊断访谈。进行 Cox 比例风险回归分析，根据父亲和父辈的 AD 和 DD 病史、父母分离以及后代和家庭背景特征，预测首次使用的发生、从首次使用到首次 AD 症状的转变、以及从首次使用到 AD 诊断的转变。父系/父系 DD/AD 基于 DSM-III-R；后代和母亲 AD 均基于 DSM-IV 标准。结果父亲 DD/AD 预测所有转变的后代风险都会增加，遗传效应表明遗传效应会影响转变为 AD 诊断的比率。父母分居预示着早期饮酒的风险增加，但 AD 症状发作和 AD 发作的转变率降低。没有发现分居和家庭风险（以父亲或父辈 DD/AD 为索引）之间的相互作用。结论研究结果强调了父母分居和父亲的物质依赖在预测后代饮酒开始时间以及从青春期到成年早期的问题方面的贡献。
BackgroundWe examined associations between parental separation during childhood and offspring alcohol involvement, adjusting for genetic and environmental risks specific to parental alcohol (AD) and cannabis/other illicit drug dependence (DD).MethodsThe sample consisted of 1,828 offspring of male twins from the Vietnam Era Twin (VET) Registry, who completed a telephone diagnostic interview. Cox proportional hazards regression analyses were conducted predicting onset of first use, transition from first use to first AD symptom, and transition from first use to AD diagnosis from paternal and avuncular AD and DD history, parental separation, and offspring and family background characteristics. Paternal/avuncular DD/AD was based on the DSM-III-R; offspring and maternal AD were based on DSM-IV criteria.ResultsPaternal DD/AD predicted increased offspring risk for all transitions, with genetic effects suggested on rate of transitioning to AD diagnosis. Parental separation was predictive of increased risk for early alcohol use, but a reduced rate of transition to both AD symptom onset and onset of AD. No interactions between separation and familial risk (indexed by paternal or avuncular DD/AD) were found.ConclusionsFindings highlight the contribution of both parental separation and paternal substance dependence in predicting timing of offspring alcohol initiation and problems across adolescence into early adulthood.