Longitudinal Reproducibility and Accuracy of Pseudo-Continuous Arterial Spin-labeled Perfusion MR Imaging in Typically Developing Children
Longitudinal Reproducibility and Accuracy of Pseudo-Continuous Arterial Spin-labeled Perfusion MR Imaging in Typically Developing Children
复制标题
DOI：
10.1148/radiol.12111509
复制
发表时间：
2012-05-01
期刊：
影响因子：
19.7
通讯作者：
Wang, Danny J. J.
中科院分区：
文献类型：
--
作者：
Jain, Varsha;Duda, Jeffrey;Wang, Danny J. J.
目的：评价伪连续动脉自旋标记(PCASL)磁共振灌注成像在典型发育儿童脑血流量(CBF)测量中的纵向可重复性和准确性。材料和方法：获得机构评审委员会的批准和知情同意。22名7-17岁的儿童接受了重复的pCASL检查，间隔2-4周，使用3-T磁共振成像仪，同时测量活体血液T1和动脉通过时间。以相位对比(PC)磁共振成像作为全球血流量的参考标准。采用组内相关系数(ICC)和受试者内变异系数(WSCV)评价其准确性和重复性。结果：结合受试者在体血T1测量，pCASL相对于PC MR成像参考标准的准确性提高(ICC：0.32比0.58)。通过使用基于人群的血液T1模型，ICC进一步增加到0.65。此外，使用pCASL测量的CBF在全脑(ICC=0.61，WSCV=15%)、灰质(ICC=0.65，WSCV=14%)和16个脑区(平均ICC=0.55，WSCV=17%)的纵向可重复性中到良好水平。在研究的儿童队列中，平均动脉通过时间为1538毫秒+/-123(标准差)，随着年龄的增长有增加的趋势(P=.043)。结论：纳入血液T1的发育变化对于提高儿童和青少年pCASL CBF测量的准确性很重要；无创性、准确性和纵向重复性应有助于pCASL灌注MR成像在神经发育研究中的应用。(C)RSNA，2012年
Purpose: To evaluate the longitudinal repeatability and accuracy of cerebral blood flow (CBF) measurements by using pseudo-continuous arterial spin-labeled (pCASL) perfusion magnetic resonance (MR) imaging in typically developing children.Materials and Methods: Institutional review board approval with HIPAA compliance and informed consent were obtained. Twenty-two children aged 7-17 years underwent repeated pCASL examinations 2-4 weeks apart with a 3-T MR imager, along with in vivo blood T1 and arterial transit time measurements. Phase-contrast (PC) MR imaging was performed as the reference standard for global blood flow volume. Intraclass correlation coefficient (ICC) and within-subject coefficient of variation (wsCV) were used to evaluate accuracy and repeatability.Results: The accuracy of pCASL against the reference standard of PC MR imaging increased on incorporating subjectwise in vivo blood T1 measurement (ICC: 0.32 vs 0.58). The ICC further increased to 0.65 by using a population-based model of blood T1. Additionally, CBF measurements with use of pCASL demonstrated a moderate to good level of longitudinal repeatability in whole brain (ICC = 0.61, wsCV = 15%), in gray matter (ICC = 0.65, wsCV = 14%), and across 16 brain regions (mean ICC = 0.55, wsCV = 17%). The mean arterial transit time was 1538 msec +/- 123 (standard deviation) in the pediatric cohort studied, which showed an increasing trend with age (P = .043).Conclusion: Incorporating developmental changes in blood T1 is important for improving the accuracy of pCASL CBF measurements in children and adolescents; the noninvasive nature, accuracy, and longitudinal repeatability should facilitate the use of pCASL perfusion MR imaging in neurodevelopmental studies. (C) RSNA, 2012