Applying genomics to the study of complex disease
Applying genomics to the study of complex disease
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DOI：
10.1055/s-2006-960167
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发表时间：
2007-02-01
影响因子：
4.2
通讯作者：
Lazaridis, Konstantinos N.
中科院分区：
文献类型：
--
作者：
Juran, Brian D.;Lazaridis, Konstantinos N.
在基因组学和相关学科领域的新兴进展的推动下，对解剖复杂人类疾病的遗传和环境成分的兴趣正在增长。提高对复杂肝脏疾病如胆囊结石、非酒精性脂肪肝、病毒性肝炎和肝细胞癌的发病机制的认识仍然是临床和实验肝病学家的目标。尽管科学进步和技术进步，从基因组的角度阐明复杂肝脏疾病的潜在机制将是苛刻的。基因组结构和功能的复杂性，疾病的异质性，环境对疾病发展和进展的影响，以及表观遗传学都有助于这一挑战。为了克服这些障碍，除了不同科学学科之间的协调奋进之外，还需要关于生物系统和人类疾病的新概念框架。以综合方式破译复杂肝脏疾病发病机制的基因组，转录和翻译方面将导致更好的预测，诊断和治疗。
The interest in dissecting the genetic and environmental components of complex human disease is growing, fueled by the emerging advances in the field of genomics and related disciplines. Improved understanding of the pathogenesis of complex liver diseases such as gallbladder stones, nonalcoholic fatty liver disease, viral hepatitis, and hepatocellular carcinoma remains a goal of the clinical and experimental hepatologist alike. Despite the scientific progress and technological advancement, elucidating the underlying mechanisms of complex hepatic diseases from the genomic standpoint will be demanding. Complexity of genomic structure and function, disease heterogeneity, influence of the environment on disease development and progression, and epigenetics all contribute to the challenge. To overcome these obstacles, novel conceptual frameworks regarding biological systems and human diseases are necessary in addition to a coordinated endeavor among different scientific disciplines. Deciphering in an integrated fashion the genomic, transcriptional, and translational aspects of the pathogenesis of complex liver diseases will lead to their better prediction, diagnostics, and treatment.