Phenolic compounds from Sidastrum micranthum (A. St.-Hil.) fryxell and evaluation of acacetin and 7,4'-Di-O-methylisoscutellarein as motulator of bacterial drug resistence
Phenolic compounds from Sidastrum micranthum (A. St.-Hil.) fryxell and evaluation of acacetin and 7,4'-Di-O-methylisoscutellarein as motulator of bacterial drug resistence
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DOI：
10.1590/s0100-40422011000800016
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Siqueira-Junior, José P.
中科院分区：
文献类型：
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作者：
Gomes, Roosevelt A.;Ramirez, Rafael R. A.;Siqueira-Junior, José P.
从小菱叶木Sidastrum micranthum（A.圣- Hil.）从锦葵科锦葵属植物Fryxell中分离得到间甲氧基对羟基苯甲醛、邻羟基苯甲酸、金合欢素、槲皮素、7，4 ′-二-O-甲基异黄芩素、芫花素和替皮苷。通过光谱数据分析鉴定了这些化合物的结构。金合欢素和7，4 '-二-O-甲基异黄芩素没有表现出相关的抗菌活性（MIC = 256 μ g/mL），它们调节抗生素的活性，即与64 μ g/mL（MIC）的抗生素组合时，观察到诺氟沙星和溴化乙锭的MIC降低两倍;关于四环素和红霉素，仅观察到7，4 ′-二-O-甲基异黄芩素的MIC降低两倍。
From the aerial parts of Sidastrum micranthum (A. St.-Hil.) Fryxell (Malvaceae) were isolated m-methoxy-p-hydroxy-benzaldehyde, o-hydroxy-benzoic acid, acacetin, quercetin, 7,4'-Di-O-methylisoscutellarein, genkwanin and tiliroside. These compounds were identified by data analyses of spectroscopic methods. Although acacetin and 7,4'-Di-O-methylisoscutellarein did not display relevant antibacterial activity (MIC = 256 mu g/mL), they modulated the activity of antibiotics, i.e. in combination with antibiotics at 64 mu g/mL (MIC), a two-fold reduction in the MIC was observed for norfloxacin and ethidium bromide; regarding tetracycline and erythromycin a two-fold reduction in the MIC was observed only with 7,4'-Di-O-methylisoscutellarein.