SURFACE-IMMOBILIZED POLYETHYLENE OXIDE FOR BACTERIAL REPELLENCE
SURFACE-IMMOBILIZED POLYETHYLENE OXIDE FOR BACTERIAL REPELLENCE
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DOI：
10.1016/0142-9612(92)90160-p
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发表时间：
1992-01-01
期刊：
影响因子：
14
通讯作者：
HUBBELL, JA
中科院分区：
文献类型：
--
作者：
DESAI, NP;HOSSAINY, SFA;HUBBELL, JA
聚对苯二甲酸乙二醇酯薄膜的表面改性与聚环氧乙烷（18 500克/摩尔）使用前面描述的溶液技术。研究了这些膜的抗细菌粘附性。在聚合物基质上的胰蛋白酶大豆肉汤、人血浆和人血清中培养最常与植入物感染相关的三种细菌菌株，表皮葡萄球菌、金黄色葡萄球菌和铜绿假单胞菌。与未处理的对照聚对苯二甲酸乙二醇酯相比，在聚环氧乙烷改性的基材上观察到粘附细菌的显著减少（70 - 95%）。使用聚环氧乙烷进行表面改性可降低植入物相关感染的风险。观察到血浆纤维蛋白原在所有这三种物质在聚环氧乙烷改性和对照聚对苯二甲酸乙二醇酯材料上的粘附中起重要作用。
Polyethlene terephthalate films were surface-modified with polyethylene oxide (18 500 g/mol) using a solution technique described previously. These films were investigated for their resistance to bacterial adhesion. Three bacterial strains most commonly associated with implant infections, Staphylococcus epidermidis, Staphylococcus aureus and Pseudomonas aeruginosa, were cultured in tryptic soya broth, human plasma and human serum on the polymeric substrates. Significant reductions (between 70 and 95%) in adherent bacteria were observed on the polyethylene oxide-modified substrates compared to the untreated control polyethylene terephthalate. Surface modification with polyethylene oxide may reduce the risk of implant-associated infections. Plasma fibrinogen was observed to play an important role in the adhesion of all three of these species on both the polyethylene oxide-modified and control polyethylene terephthalate materials.